The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery
Not Applicable
Completed
- Conditions
- Lung Cancer
- Interventions
- Registration Number
- NCT03936140
- Lead Sponsor
- Seoul St. Mary's Hospital
- Brief Summary
During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- elective video-assisted thoracoscopic surgery (VATS) lobectomy
- 20 < age < 75
- American Society of Anesthesiologists (ASA) classification I~III
Exclusion Criteria
- ASA classification IV
- New York Heart Association (NYHA) class III~IV
- Severe obstructive lung disease / restrictive lung disease
- Pulmonary hypertension
- End-stage organ disease (i.e. hepatic failure, renal failure)
- Arrhythmia
- Previous history of thoracic surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Distilled water Distilled water Distilled water Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. Iloprost 20 Inhaled iloprost Iloprost 20μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position. Iloprost 10 Inhaled iloprost Iloprost 10μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
- Primary Outcome Measures
Name Time Method PaO2(partial pressure of arterial oxygen) 30 min after treatment ABGA
Pulmonary shunt fraction 30 min after treatment Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Seoul St.Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Seoul St.Mary's Hospital🇰🇷Seoul, Korea, Republic of