The Effect of Iloprost on Arterial Oxygenation and Shunt Fraction During One-lung Ventilation for Lung Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- PaO2(partial pressure of arterial oxygen)
研究概览
简要总结
During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective video-assisted thoracoscopic surgery (VATS) lobectomy
- •20 < age < 75
- •American Society of Anesthesiologists (ASA) classification I~III
排除标准
- •ASA classification IV
- •New York Heart Association (NYHA) class III~IV
- •Severe obstructive lung disease / restrictive lung disease
- •Pulmonary hypertension
- •End-stage organ disease (i.e. hepatic failure, renal failure)
- •Arrhythmia
- •Previous history of thoracic surgery
研究组 & 干预措施
Iloprost 10
Iloprost 10μg of inhaled iloprost (Ventavis®)
Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
干预措施: Inhaled iloprost (Drug)
Iloprost 20
Iloprost 20μg of inhaled iloprost (Ventavis®)
Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
干预措施: Inhaled iloprost (Drug)
Distilled water
Distilled water
Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
干预措施: Distilled water (Drug)
结局指标
主要结局
PaO2(partial pressure of arterial oxygen)
时间窗: 30 min after treatment
ABGA
Pulmonary shunt fraction
时间窗: 30 min after treatment
Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2)
次要结局
未报告次要终点
研究者
Wonjung Hwang
Assistant professor
Seoul St. Mary's Hospital