The Effect of Iloprost on Oxygenation During One-lung Ventilation for Lung Surgery

Not Applicable

Completed

• Conditions: Lung Cancer
• Interventions: Drug: Distilled water; Drug: Inhaled iloprost

• Registration Number: NCT03936140
• Lead Sponsor: Seoul St. Mary's Hospital

Brief Summary

During one-lung ventilation in patients undergoing thoracic surgery, the persistent flow in the non-ventilated lung increases intrapulmonary shunt and decreases systemic arterial oxygenation. This prospective, randomized, double blind study was conducted to evaluate the effects of inhaled iloprost during one-lung ventilation on arterial oxygenation and shunt fraction during thoracic surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-04
• Primary Completion: 2018-10-24
• Study Completion: 2018-10-24
• Study First Submitted: 2019-04-08
• Status Verified: 2019-05
• Study First Submitted QC: 2019-05-01
• Last Update Submitted: 2019-05-01
• Study First Posted: 2019-05-03
• Last Update Posted: 2019-05-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• elective video-assisted thoracoscopic surgery (VATS) lobectomy
• 20 < age < 75
• American Society of Anesthesiologists (ASA) classification I~III

Exclusion Criteria

• ASA classification IV
• New York Heart Association (NYHA) class III~IV
• Severe obstructive lung disease / restrictive lung disease
• Pulmonary hypertension
• End-stage organ disease (i.e. hepatic failure, renal failure)
• Arrhythmia
• Previous history of thoracic surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Distilled water	Distilled water	Distilled water Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
Iloprost 20	Inhaled iloprost	Iloprost 20μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.
Iloprost 10	Inhaled iloprost	Iloprost 10μg of inhaled iloprost (Ventavis®) Study drug was inhaled to ventilated lung through a nebulized system in inspiratory limb after one-lung ventilation in the lateral decubitus position.

Primary Outcome Measures

Name	Time	Method
PaO2(partial pressure of arterial oxygen)	30 min after treatment	ABGA
Pulmonary shunt fraction	30 min after treatment	Qs/Qt = (CcO2-CaO2) / (CcO2-CvO2)

Trial Locations

Locations (1)

Seoul St.Mary's Hospital; 🇰🇷 Seoul, Korea, Republic of