Serum Folic Acid Status, Genotyping MTHFR 677C-->T of the Mother and Serum Folic Acid Status, DNA Methylation of IGF2 Gene of the Children: East Jakarta Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 254
- 试验地点
- 1
- 主要终点
- Serum folic acid status
研究概览
简要总结
This study is part of the East Jakarta Cohort Study to assess the current micronutrient status of the mothers and their children. The study also includes the assessment of genotyping of MTHFR 677C-->T of the mother and DNA methylation of IGF2 gene of the children.
详细描述
The initial study recruited 315 mothers in the public health centre and one district hospital in East Jakarta. The follow-up study is able to re-visit the 127 of them. This also includes 127 peers of the subject that lives in the same neighbourhood. The design of the study is case-cohort design, part study of the existing cohort. The assessment of the follow-up study includes the mother and the children born in the initial study. Anthropometric measurement, socioeconomic data from a structured questionnaire, biomarker assessment, blood pressure were obtained from the subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •participant in the previous study
- •apparently healthy
- •data complete
- •voluntarily to participate
排除标准
- •not complete data
- •refuse to participate in the study
结局指标
主要结局
Serum folic acid status
时间窗: December 2018 - March 2019
The measurement of serum folic acid status is using LC-MS/MS
Genotyping MTHFR 677C-->T
时间窗: December 2018 - March 2019
The assessment of MTHFR 677C--\>T using Real Time PCR
DNA methylation of IGF2 gene
时间窗: December 2018 - March 2019
DNA methylation of IGF2 gene using pyrosequencing method
次要结局
- Serum Adiponectin(December 2018-March 2019)
- Blood pressure(December 2018-March 2019)
- Serum Homocysteine(December 2018-March 2019)
研究者
Lestari Octavia
MSc
Indonesia University