跳至主要内容
临床试验/NCT01173705
NCT01173705终止不适用

Genetic and Nutritional Factors Involved in Obesity-related Inflammation and Insulin Resistance

Vanderbilt University1 个研究点 分布在 1 个国家目标入组 62 人开始时间: 2011年6月最近更新:
适应症

试验速览

阶段
不适用
状态
终止
入组人数
62
试验地点
1
主要终点
Examine the relationship between omega-3 content and inflammatory and oxidative stress markers

研究概览

简要总结

In this project, we propose to recruit lean and obese subjects with different ethnic background (African Americans and Caucasians) to study the alterations of lipid and carbohydrate metabolism and determine whether these disturbances are linked to genetic, inflammatory, oxidative stress, and/or nutritional factors. Because systemic inflammation and insulin resistance are frequent features of obesity, we postulate that an unbalanced diet with high saturated- and low omega 3-fatty acids is linked to obesity-related inflammation and insulin resistance. We propose to investigate fatty acid metabolism and determine the links between fatty acid composition and oxidative stress in tissues of lean and obese subjects. We propose the following aims:

Specific Aim 1: Evaluate nutrient intake in lean and obese subjects using the standard NHANES Food Questionnaire.

Specific Aim 2: Evaluate the fatty acid composition, including omega-3, in adipose tissue depots, blood monocytes and skeletal muscle, and examine the relationship between omega-3 content and inflammatory and oxidative stress markers.

Specific Aim 3: Compare the effects of omega-3 and saturated FA supplementation on inflammatory and oxidative stress markers in vitro in adipose tissue explants, preadipocytes and monocyte culture.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18-65 years of age
  • Undergoing elective abdominal or bariatric surgery

排除标准

  • Intercurrent infections
  • Active cancer diagnosis within 5 years
  • Use of medications for diabetes or hyperlipidemia
  • Use of glucocorticoids or anti-inflammatory drugs

结局指标

主要结局

Examine the relationship between omega-3 content and inflammatory and oxidative stress markers

时间窗: 5 years

We will evaluate fatty acid composition in adipose tissues depots, blood monocytes, and skeletal muscle to examine the relationship between omega-e content and inflammatory and oxidative stress markers.

次要结局

  • Evaluate nutrient intake(5 years)
  • Compare effects of omega-3 and saturated fatty acid supplementation on inflammatory and oxidative stress markers (in vitro)(5 years)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Robyn Tamboli

Research Assistant Professor

Vanderbilt University

研究点 (1)

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