Effect of Diet Orange Soda on Urinary Lithogenicity
Not Applicable
Completed
- Conditions
- Kidney StonesNephrolithiasisUrolithiasis
- Interventions
- Dietary Supplement: Orange soda
- Registration Number
- NCT01330940
- Lead Sponsor
- VA New York Harbor Healthcare System
- Brief Summary
Beverages containing citrate may be useful in increasing urine citrate content and urine pH. Such changes in urine chemistry could help prevent kidney stones. Diet orange soda has more citrate than other similar beverages. The investigators are interested in whether diet soda will improve urine chemistry in the appropriate manner.
- Detailed Description
The effect of orange soda compared with water in changing 24 hour urine citrate excretion in mg/day will be determined.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- 18-65 years old
- able to sign consent
- ability to reliably urinate into a vessel and measure urine volume
Exclusion Criteria
- prior history of nephrolithiasis
- a known history of metabolic bone disease
- hyperthyroidism
- hyperparathyroidism or chronic kidney disease
- current use of diuretics
- current use of potassium citrate or other oral alkali supplementation and
- use of calcium supplementation that could not be stopped
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Water drinking Orange soda 32 ounces of water/24 hours orange soda drinking Orange soda 32 ounces orange soda
- Primary Outcome Measures
Name Time Method Change in urine citrate content 1 week Citrate is measured in 24h urine sample and expressed as mg/day
- Secondary Outcome Measures
Name Time Method Change in urine pH One week urine pH is measured in a 24h urine sample and has no units
Trial Locations
- Locations (1)
New York Harbor VA Medical Center
🇺🇸New York City, New York, United States