The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 82
- 试验地点
- 1
- 主要终点
- thrombin generation levels
研究概览
简要总结
In total 50 subjects with iron deficiency anemia treated with intravenous iron are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant before iron treatment. The investigators will measure the thrombin generation in plasma assessed by the calibrated automated thrombogram (CAT). patient will go face to face interview and will be asked to answer structured questionnaire which will include information on demographics, clinical data ( fever, allergies , etc.) and comorbidities
Two weeks after completing intravenous iron administration additional blood samples will be taken: thrombin generation will be measured
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age >18 years
- •Iron deficiency anemia that did not response to oral iron treatment and is planned to receive iron supplement intravenously.
- •Signing the informed consent
- •exclusion criteria:
- •chronic inflammatory disease
- •renal failure
- •Malignancy
- •Infectious disease
- •Other reason for anemia except iron deficiency anemia.
- •Pregnant women
- •Use of anti aggregating agents or anticoagulants
排除标准
- 未提供
结局指标
主要结局
thrombin generation levels
时间窗: 10 weeks
次要结局
未报告次要终点
研究者
Elias mazen
prof mazen elias
HaEmek Medical Center, Israel
