The Purpose of the Study is to Examine Whether Iron Deficiency Anemia is Associated With Increased Production of Thrombin and Whether Correction of Anemia by Providing Iron Intravenously Causes a Significant Reduction in Production of Thrombin.
- Conditions
- Iron Deficiency Anemias
- Registration Number
- NCT02129907
- Lead Sponsor
- HaEmek Medical Center, Israel
- Brief Summary
In total 50 subjects with iron deficiency anemia treated with intravenous iron are planned for inclusion in this trial. After signing an informed consent a blood sample will be obtained from each participant before iron treatment. The investigators will measure the thrombin generation in plasma assessed by the calibrated automated thrombogram (CAT). patient will go face to face interview and will be asked to answer structured questionnaire which will include information on demographics, clinical data ( fever, allergies , etc.) and comorbidities
Two weeks after completing intravenous iron administration additional blood samples will be taken: thrombin generation will be measured
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 82
- age >18 years
- Iron deficiency anemia that did not response to oral iron treatment and is planned to receive iron supplement intravenously.
- Signing the informed consent
exclusion criteria:
- chronic inflammatory disease
- renal failure
- Malignancy
- Infectious disease
- Other reason for anemia except iron deficiency anemia.
- Pregnant women
- Use of anti aggregating agents or anticoagulants
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method thrombin generation levels 10 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Haemek medical center
🇮🇱Afula, Israel