A Study of Tooth Erosion in People With Esophagogastric Cancer

Not Applicable

Recruiting

• Conditions: Esophagogastric Cancer
• Interventions: Other: Survey; Other: Intra-oral camera; Other: Optional Salvia sample

• Registration Number: NCT05612048
• Lead Sponsor: Memorial Sloan Kettering Cancer Center

Brief Summary

The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer, pancreatic cancer, breast cancer, head and neck cancer, or non-small cell lung cancer, or a healthy volunteer.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-11-03
• Study First Submitted: 2022-11-03
• Study First Submitted QC: 2022-11-03
• Study First Posted: 2022-11-10
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-18
• Last Update Posted: 2025-02-19
• Primary Completion: 2025-11
• Study Completion: 2025-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Subject is willing and able to provide written informed consent.
• Patients with a history of esophagogastric, HNSCC, PDAC, CRC, or NSCLC or healthy controls
• Patients must be able to fully comprehend and complete the survey and be willing to have pictures taken of their teeth with a camera or intra-oral camera.
• Patients must be able to understand English language or have access to adequate translation services.
• Age ≥ 18 years old.

Exclusion Criteria

• Subjects without evaluable molars or with significant molar dental work precluding dentists from assessing enamel status, Note: evaluable is defined as having bilateral assessable mandibular molars, or erosions present in the remaining assessable quadrants.
• For healthy controls only, patients cannot have a non-skin cancer history nor presenting for a procedure evaluating reflux symptoms.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Healthy volunteers who have not been diagnosed with cancer	Intra-oral camera	Healthy controls will be defined as those without a known or suspected invasive cancer history and excluding those undergoing a procedure for symptomatic reflux.
Patients diagnosed with esophagogastric cancer	Survey	Patients have completed the intervention once completing the survey, undergoing dental imaging and future patients will also provide an optional saliva sample.
Patients diagnosed with esophagogastric cancer	Intra-oral camera	Patients have completed the intervention once completing the survey, undergoing dental imaging and future patients will also provide an optional saliva sample.
Patients diagnosed with esophagogastric cancer	Optional Salvia sample	Patients have completed the intervention once completing the survey, undergoing dental imaging and future patients will also provide an optional saliva sample.
Patients diagnosed with colorectal, pancreatic, breast, head and neck, or non-small cell lung cancer	Survey	Patients undergo consenting and dental imaging during their routine visits at MSK.
Patients diagnosed with colorectal, pancreatic, breast, head and neck, or non-small cell lung cancer	Intra-oral camera	Patients undergo consenting and dental imaging during their routine visits at MSK.
Healthy volunteers who have not been diagnosed with cancer	Survey	Healthy controls will be defined as those without a known or suspected invasive cancer history and excluding those undergoing a procedure for symptomatic reflux.

Primary Outcome Measures

Name	Time	Method
The incidence of dental erosions	1 year	scored with a modified BEWE index.

Trial Locations

Locations (1)

Memorial Sloan Kettering Cancer Center (All Protocol Activities); 🇺🇸 New York, New York, United States