Comparison of effectiveness of 2 injections Dexmedetomidine and Labetalol in managing increase in blood pressure and heart rate occuring during passage of breathing tube into windpipe in patients coming for planned surgery before general anesthesia
Phase 3
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2024/07/069732
- Lead Sponsor
- Rajendra Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA Grade I & II ,Elective surgery requiring general anesthesia with endotracheal intubation
Exclusion Criteria
Patient contraindicated to beta blockers,Hypertensive patients,patients on anti hypertensives,Systolic BP less than 120 mm of hg , HR less than 60/min,Evidence of anticipated difficult airway,Drug allergy to dexmedetomidine and labetalol,Pregnant patients,Ischemic heart disease,Cerebrovascular accidents,patient refusal,intubation attempts more than 2 times
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the efficacy of dexmedetomidine 1 µg/kg and labetalol 0.3 <br/ ><br>mg/kg in blunting the hemodynamic stress response to laryngoscopy and intubationTimepoint: 1)after drug administration <br/ ><br>2)after induction <br/ ><br>3)1 minute after induction <br/ ><br>4)2 minute after induction <br/ ><br>5)3 minute after induction <br/ ><br>6)5 minute after induction <br/ ><br>7)10 minute after induction <br/ ><br>8)15 minute after induction
- Secondary Outcome Measures
Name Time Method 1)To observe for any adverse effect related to dexmedetomidine and <br/ ><br>labetalol <br/ ><br>2)To determine and compare the level of sedation achieved before intubation after administration <br/ ><br>of dexmedetomidine and labetalolTimepoint: 1)after drug administration <br/ ><br>2)after induction <br/ ><br>3)1 minute after induction <br/ ><br>4)2 minute after induction <br/ ><br>5)3 minute after induction <br/ ><br>6)5 minute after induction <br/ ><br>7)10 minute after induction <br/ ><br>8)15 minute after induction