Characterization of reward-processing, resting-state metabolism, social cognition, social comparison based motivation between patients with therapy-resistant OCD and substance abuse disorder and healthy participants
Not Applicable
Recruiting
- Conditions
- F42F10.2Obsessive-compulsive disorder
- Registration Number
- DRKS00008583
- Lead Sponsor
- niklinik KölnKlinik für Psychiatrie und Psychotherapie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
• Age 18-65
• Assessed substance abuse disorder or OCD (ICD-10 or DSM-IV criteria)
• Patient approves to be evaluated
• Disorder was treated with a DBS
• Patients have to be capable to give consent
• Written informed consent
Exclusion Criteria
• paranoide-hallucinatory episode in the last 6 months
• current depressive disorder
• current organic or pharmacological psychotic episode
• pregnancy or breast-feeding
• suicidal tendencies or violent behaviour in the last six weeks
• serious or instable physical disease or brain tumor
• clinical relevant internal or neurological disease
• Withdrawal of informed consent
• FDG-PET contradiction
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change of impulsivity will be assesed with a delay discounting paradigma which results in a k-parameter (a high k-paramater indicates high impulsivity and a low k-parameter indicates low impuslvity) and the the baseline k-parameter (assesment before operation) will be compared to the acute effects of the on/off condition.
- Secondary Outcome Measures
Name Time Method Change of resting-state metabolism will be assessed with FDG-PET. Effects of modulation shall be visualised by comparing the on and off condition.