Reward mechanisms, mood and motivational symptoms in Parkinson's disease: an experimental approach

Recruiting

• Conditions: emotional blunting; lack of initiative; 10028037

• Registration Number: NL-OMON31022
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

-Idopathic Parkinson's disease
-Informed consent

Exclusion Criteria

-Other concurrent neurological diseases than PD
-Concurrent psychiatric disease
-Use of psychopharmacological medication
-Abuse of alcohol and drugs
-Cognitive deterioration as operationalized by a score of <23 on the MMSE
-Use of levodopa preparations of dopamine agonists.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameters are the performance on neuropsychiatric and<br /><br>neuropsychological tests for both groups, including assessments of cognitive<br /><br>status, mood, apathy, and an observation of spontaneous self-reward behaviour.<br /><br>These outcome measures will be rated on three different testing days, before<br /><br>and after the administration of methylphenidate, pramipexole or placebo. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>