In Utero Exposure to SARS-CoV-2 (COVID-19) and Cardiovascular and Metabolic Endpoints in Early Life
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 86
- 试验地点
- 1
- 主要终点
- Aortic pulse-wave velocity
研究概览
简要总结
Since its initial outbreak in late 2019, coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2 has ravaged the globe, causing illness characterized by inflammation and impaired oxygen levels. As a particularly vulnerable group, pregnant women have had a heightened prevalence and severity of infection. In this context, a new population of children has emerged who were exposed to maternal COVID-19 in the womb. As maternal diseases during pregnancy may impact the health of offspring over the life course, health outcomes among these individuals must be urgently evaluated. In the current study, the investigators will leverage a perinatal biorepository comprised of pregnant women with and without COVID-19 to delineate the metabolic and cardiovascular risk profiles of these offspring. This work stands to benefit the burgeoning population of children exposed to COVID-19 in the womb and to deepen the mechanistic understanding of developmental origins of cardiometabolic disease with respect to maternal infections.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 9 Months 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Mother with or without prenatal COVID-19 who was enrolled in the MGH COVID-19 Perinatal Biorepository and her child (9-24 months old)
排除标准
- •Child with any history of documented COVID-19
- •Mother who received the COVID-19 vaccine during pregnancy with her child
- •Significant chronic illness in mother or child judged by the investigator to represent a contraindication to study participation
结局指标
主要结局
Aortic pulse-wave velocity
时间窗: Baseline
次要结局
- Beta index of aortic stiffness using echocardiogram(Baseline)
- Urinary angiotensin peptide levels(Baseline)
- Urinary angiotensin converting enzyme (ACE) levels(Baseline)
- Aortic intima-media thickness using echocardiogram(Baseline)
- Left ventricular dimensions(Baseline)
- Left ventricular mass(Baseline)
- Skinfold thicknesses (subscapular, triceps)(Baseline)
- Weight-for-length z-score(Baseline)
- Systolic and diastolic blood pressure(Baseline)
研究者
Lindsay Fourman, MD
Assistant Professor of Medicine
Massachusetts General Hospital