Detection Of Monocytes/Macrophages Function And Tim-3 Expression In Septic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- systemic inflammatory response to infection with organ dysfunction, hypoperfusion, or hypotension
研究概览
简要总结
The imbalance between anti- and pro-inflammation often occurs in patients with sepsis. And continuous such imbalance could lead to immunoparalysis, which is characterized by loss of delayed type hypersensitivity, failure of primary infections eradication, and a predisposition of secondary nosocomial infections development. However, in which phase of sepsis does immunoparalysis occur is still unknown. So this study aims to tentatively understand this problem by checking monocytes/macrophages' antigen presentation and cytokine secretion，and by checking monocytes/macrophages' expression of Tim-3 (the T cell transmembrane, immunoglobulin, and mucin-3), which is an inhibitory regulatory molecule, in sepsis patients' peripheral blood mononuclear cells.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age over 18 years old;
- •Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 ℃ or lower than 36 ℃ (b)respiratory rate above 20/min, or carbon dioxide partial pressure below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than < 4,000/μl or less than 10% of bands.
- •Clinically suspected infection;
排除标准
- •were under 18 years of age;
- •were refused by the patients or his/her familiality;
- •were suffering from acquired immunodeficiency syndrome,viral hepatitis,autoimmune diseases and hematology;
- •use medicine which can affect immune system,such as Glucocorticoid and Immunosuppressant
- •died within 24h after being taken into the ICU, or refused to get involved in the study, or gave up treatment during the period of observation
结局指标
主要结局
systemic inflammatory response to infection with organ dysfunction, hypoperfusion, or hypotension
时间窗: within 24 hours after enter experimental group
次要结局
未报告次要终点
研究者
Jia Li
Medical doctor of Department of Respirtory Disease
Chinese PLA General Hospital