Outcome of URS in Fresh Versus Recurrent Cases of Stone Ureter

Not yet recruiting

• Conditions: Stone Ureter
• Interventions: Procedure: Ureteroscopy

• Registration Number: NCT06592469
• Lead Sponsor: Assiut University

Brief Summary

Comparison of Ureteroscopy in fresh versus recurrent cases of stone ureter

Detailed Description

Urolithiasis is a common cause of both urology outpatient clinic and emergency room encounters. Approximately 75-90% of ureteral stones pass spontaneously. from this point of view other managements of ureteric stones either ESWL, ureteroscopy or open surgery according to location, site, size, and density. Ureteroscopy is commonly used to diagnose and treat kidney and ureteral stones, ureteral strictures, and urothelial cancers. Semirigid URS is the gold standard of treatment for ureteral stones. High success rates and low morbidity have been reported in semirigid URS. but complications still occur in some cases. The possibility to predict their occurrence should influence patient advisement and better case selection. there are many predictors of successful URS as age, gender, previous ESWL, and stone character. In addition, the impacted stone is a risk factor, and it is described in the literature as ureteral wall thickness, higher grades of hydronephrosis, ureteral stricture, polyp, inflammatory reaction, and difficulty to introduce the guide wire. the literature is very poor in illustrating the previous procedures as a predictor of successful URS only seen in very few original articles as second-time URS after any procedure decreases the rate of success, so it is a point of research that Amr Moustafa aims to clarify. Amr Moustafa will conduct a prospective study to evaluate the outcomes of URS for stones in the fresh and recurrent cases.

Study Timeline

• Status Verified: 2024-09
• Study First Submitted: 2024-09-05
• Study First Submitted QC: 2024-09-11
• Last Update Submitted: 2024-09-11
• Study First Posted: 2024-09-12
• Last Update Posted: 2024-09-12
• Study Start: 2024-10-01
• Primary Completion: 2025-10-01
• Study Completion: 2025-11

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• • all cases with middle and lower ureteric stone candidate for endoscopy.

  • Stone 15mm or less.

Exclusion Criteria

• • Patients with a ureteral stent.

  • Patient refusing participation.
  • Pregnant woman.
  • Active urinary tract infection.
  • Comorbidities prevent intervention including bleeding tendency or uncorrectable coagulation profile.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Fresh cases	Ureteroscopy	Outcome of URS in fresh stone ureter
Recurrent cases	Ureteroscopy	Outcome of URS in recurrent cases of stone ureter post ESWL ,URS , open surgery

Primary Outcome Measures

Name	Time	Method
Stone free rate of Urereroscopy in fresh versus recurrent cases of stone ureter	1 day post operative by MSCTKUB or Plain KUB to determine residual stones post operative	• Stone free rate with a mean operative time of 1 hr by MSCTKUB or Plain KUB to determine residual stones post operative

Secondary Outcome Measures

Name	Time	Method
• Rate of intraoperative findings in each group.	Intraoperative	• Rate intraoperative findings in each group by ureteroscope
• The rate of complication in each group	Intraoperative by ureteroscope and one day post operative by MSCT	To determine rate of intraoperative complications as bleeding , ureteric perforation , residual stones
• The rate of stone impaction in each group	Intraoperative by ureteroscope	Rate of stone impaction in each group fresh and recurrent cases

Trial Locations

Locations (1)

Faculty of Medicine Assiut University; 🇪🇬 Assiut, Egypt