DeBakey Cardiovascular Magnetic Resonance Study

Recruiting

Brief Summary: While advancements in cardiac magnetic resonance (CMR) have improved image quality, it is unclear how these improvements are connected to the clinical evaluation of individuals with cardiovascular disease. The aim of this large prospective registry revolves around 4 key principles: 1) utilize CMR to gain additional pathophysiologic insights into cardiovascular disease, 2) understand how CMR compares to alternative cardiovascular diagnostic modalities, 3) determine how CMR affects clinical management decisions, and 4) establish a link between CMR findings and long term prognosis in patients with known or suspected cardiovascular disease. The ultimate aim is to utilize CMR to improve patient outcomes.

CMR techniques to be studies include function, fibrosis, and flow. Focus areas include valvular heart disease, ischemic heart disease, cardiomyopathies, and vascular disease.

Detailed Description: Patient Population, Recruitment, and Consent:

Patients presenting to the Houston Methodist DeBakey CMR Laboratory will be enrolled from April 2008 to April 2038. It is expected that up to 100,000 patients may be enrolled during this period.

Subjects will be identified based on their referral to the Houston Methodist DeBakey CMR Laboratory for MRI studies during the proposed study period.

After enrollment, a registered nurse or physician will perform a thorough structured patient interview and/or review of electronic health records to document baseline medical history including cardiac risk factors, symptoms, medication usage, and prior procedure history. A small blood sample will be drawn and stored for future biomarker and/or genetic testing analysis. Annual follow up for clinical status will be performed via review of electronic health records; structured telephone interviews with the patients, relatives, and/or their health care providers; and/or the social security death index database.

Recruitment & Eligibility

Inclusion Criteria

All patients presenting to the Houston Methodist CMR Laboratory with known or suspected cardiovascular disease.

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
Cardiovascular Magnetic Resonance	Cardiovascular Magnetic Resonance	All patients who present to the Houston Methodist CMR Laboratory

Primary Outcome Measures

Name	Time	Method
Heart Failure	Through study completion, an average of once a year, up to 20 years	Congestive heart failure
Left Ventricular and/or Right Ventricular Assist Device Implantation	Through study completion, an average of once a year, up to 20 years
Mortality	Through study completion, an average of once a year, up to 20 years	All-cause mortality, Cardiovascular mortality (acute Myocardial Infarction, sudden death, heart failure, cerebrovascular, procedural), and Non-cardiovascular mortality
Heart and/or Lung Transplantation	Through study completion, an average of once a year, up to 20 years

Secondary Outcome Measures

Name	Time	Method
Arrhythmic	Through study completion, an average of once a year	Sustained ventricular tachycardia, ventricular fibrillation, nonfatal cardiac arrest, appropriate ICD therapy
Acute Cerebrovascular Accident	Through study completion, an average of once a year, up to 20 years
Acute myocardial infarction	Through study completion, an average of once a year, up to 20 years
Cardiac Interventions	Through study completion, an average of once a year, up to 20 years	Implantable cardioverter-defibrillator (ICD), pacemakers, cardiac resynchronization therapy, coronary revascularization, valvular intervention, shunt closure

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