PACTR202402557039838招募中2 期
Safety and tolerability of adjunct dexamethasone in addition to standard of care antiviral therapy compared to standard of care antiviral therapy alone for the treatment of moderate to severe Lassa Fever: An open label randomized controlled phase II clinical trial
Bernhard Nocht Institute for Tropical Medicine0 个研究点目标入组 42 人开始时间: 2024年1月16日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 42
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 19 Year(s) 至 44 Year(s)（—）
- 性别
- All
入选标准
- •Age = 18 years
- •-LF confirmed by RT-PCR with a Ct value < 30
- •-Signs of significant health impairment as evidenced by any of the following:
- •oACVPU other than A
- •oSystolic blood pressure < 90 mmHg
- •oSeizure(s), meningism, coma, focal neurological deficit
- •oAST (GOT) >3xULN
- •oALT (GPT) > 3xULN
- •oKDIGO 2 or more severe based on serum creatinine only (where preceding value of creatinine is not available, the upper limit of the normal range should be used as reference)
- •oActive macroscopic bleeding
- •oO2 saturation < 92
排除标准
- •-Pregnancy (evidenced by positive urine pregnancy test in women of child-bearing potential)
- •-Lactation following live birth
- •-Known intolerance and contra-indications to ribavirin or dexamethasone
- •-Patients who already received a corticosteroid within the preceding 7 days
- •-Investigator’s valuation that patient might be put to substantial risk by participating in this trial
- •-Patients receiving end-of-life care as judged by the investigator
研究者
相似试验
招募中
2 期
LAssa Fever Adjunct Treatment With DEXamethasoneLassa FeverNCT06222723Bernhard Nocht Institute for Tropical Medicine42
尚未招募
不适用
The effectiveness of dexamethasone as an adjunct to surgery on satisfactory resolution of chronic subdural haematomas: A randomised control trialNervous System DiseasesSurgeryChronic subdural haematomasPACTR201406000799322Research Support Unit, Aga Khan University Nairobi50
招募中
4 期
Effectiveness of intravenous dexamethasone plus adductor canal block vs adductor canal block alone to prolong analgesia following total knee arthroplasty: A randomized controlled trialPatients undergoing elective unilateral TKAOA kneeTKAAdductor canal blockPain scoreMorphine consumptionTCTR20240428001Rayong Hospital64
已完成
不适用
Evaluation of the effects of using Dexamethasone impregnated gel foam and local injection of Dexamethasone in reduction of post impacted third molar surgery side effects in patients referring to Bushehr University of Medical Sciences Dental clinicCondition 1: Post opreative pain. Condition 2: Trismus.Other specified disorders of teeth and supporting structuresCramp and spasmK08.8R25.2IRCT20201101049209N1Boushehr University of Medical Sciences114
尚未招募
不适用
dexamethasone and spinal anaesthesiaPregnancy and ChildbirthSurgeryintraoperative nausea, vomiting and hypotensionAnaesthesiaPACTR201312000577386MaCHS180