Evaluation of Gas Humidification Practices in Patients Under Invasive Mechanical Ventilation

Recruiting

• Conditions: Humidifier Lung; Mechanical Fragility; Respiratory Complication

• Registration Number: NCT06719258
• Lead Sponsor: Laval University

Brief Summary

When mechanical ventilation is initiated, a humidification method should be chosen. There is two methods: heat and humidity exchanger filters or heated humidity. The second method is recognized to be more efficient, but many external factors can influence its performance. Insufficient humidity results in observable problems, such as difficult management of respiratory secretions.

The study compare two heated humidifiers already used in ICU.

Data will be collected retrospectively from June 1, 2021.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-09-20
• Study First Submitted: 2024-11-20
• Status Verified: 2024-12
• Study First Submitted QC: 2024-12-02
• Last Update Submitted: 2024-12-02
• Study First Posted: 2024-12-05
• Last Update Posted: 2024-12-05
• Primary Completion: 2025-06
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• ≥ 18 years old
• Admitted to intensive care
• Under invasive mechanical ventilation with the usual indications for the use of a heated humidifier (prolonged invasive mechanical ventilation and / or protective ventilation requiring high respiratory rates.

Exclusion Criteria

• Mechanical venitilation immediately after surgery (<24h)
• Imminent extubation or planned intubation of very short duration (<24h)
• Enrolled in the SAVE-ICU study in the group receiving volatile agents with the AnaConDa system.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endotracheal tube occlusion requiring emergency tube change	At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)	Under-humidification episodes are defined as follows: - Occurence of endotracheal tube occlusion requiring emergency tube change
Bronchoscopy	At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)	Under-humidification episodes are defined as follows: - Occurence of performing a bronchoscopy for a suspected sub-occlusion (thick or sticky secretions), and the total number of bronchoscopies performed per patient
Tracheal saline instillations	At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)	Under-humidification episodes are defined as follows: - Occurence of tracheal saline instillations due to sticky secretions or suspected endotracheal tube sub-occlusion
Thick secretions	At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)	Under-humidification episodes are defined as follows: - Occurence of tracheal secretions describe at thick secretions (rated at 5 on the secretions scale used at the hospital) or "sticky secretions" if specified
Change humidifier settings	At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)	Under-humidification episodes are defined as follows: - The number of operations required to change humidifier settings if the plate temperature is below 62 degrees Celcius (with the MR850).

Secondary Outcome Measures

Name	Time	Method
Other elements that may be influenced by the quality of the humidification used during mechanical ventilation	At the end of the mechanical ventilation period or at 21 days ( the first of the 2 occurred)	These data will be collected: * mechanical ventilation time; * length of stay in intensive care; * ventilation pressures; * use of bronchodilator aerosols.; * Ambien room air temperature

Trial Locations

Locations (1)

Institut Universitaire de Cardiologie et de Pneumologie de Québec; 🇨🇦 Quebec, Canada