JPRN-UMIN000019926已完成未知
Clinical and neuroimaging study on preclinical Alzheimer's disease. - AMED-Preclinical
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 60years-old 至 85years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Parkinson' disease, Lewy body dementia, frontotemporal dementia, Huntington's disease, progressive supranuclear palsy or other neurodegenerative diseases other than AD. Multiple cerebral infarction, normal pressure hydrocephalus, brain tumor, epilepsy, subdural hematoma, multiple sclerosis, head trauma with sequelae will also be excluded. 2. Signs of brain infection, focal brain lesions (eg infarction) that may affect cognitive function. Individuals with subcortical small infarction or diffuse white matter lesions can be included except for those in specific lesions affecting cognition. Cortical infarcts are normally excluded. 3. Presence of pacemaker, arterial clip, artificial valves, artificial cochlea, and other magnetic/electroconductive metals in the body that may affect MRI scan. 4. Major depression or bipolar disorder within past 1 year, past history of schizophrenia, defined by DSM-IV. 5. Addiction to alcohol or other drugs within past 2 years. 6. Past history of psychiatric symptoms, agitation or abnormal behaviors that affect protocol adherence within past 3 months. 7. Presence of fatal or unstable diseases. 8. Vitamin B12 or folate deficiency, syphilis, thyroid function abnormality. 9. Admission to care home or hospitals. 10. Administration of specific drugs (defined in the procedure manual) including psychoactive drugs and warfarin. 11. Administration of any drugs in clinical trial within 1 month prior to screening. 12. Participation in clinical studies or clinical trials other than AMED preclinical. 13. Probable participation in clinical trials for Alzheimer's disease drugs during the study duration of 3 years. 14. Decision of exclusion otherwise judged by site study physician or clinical core.
研究者
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