TO COMPARE THE EFFECT OF INFUSION DOSES OF INTRAVENOUS PHENYLEPHRINE, NOREPINEPHRINE AND MEPHENTERMINE FOR MAINTENANCE OF BLOOD PRESSURE DURING SPINAL ANAESTHESIA IN CAESAREAN SECTION AND THEIR EFFECTS ON NEONATE.

The technique of choice foranaesthesia in caesarean section, is subarachnoid block. However, thistechnique is known to cause hypotension, i.e., fall in blood pressure more than20% from the baseline. Such fall in blood pressure can have deleterious effectson both the mother and the baby in utero. The incidence of maternal hypotensioncan be as high as 70- 85% if pharmacological prophylaxis isn’t used. Whenmaternal hypotension is recognized and treated promptly, the maternal and fetalmorbidity is decreased significantly. Hence, in our study, we are comparingthree vasopressor agents, viz., Phenylephrine, Noradrenaline, andMephentermine, so as to determine the best pharmacological agent to preventmaternal hypotension in parturients undergoing caesarean section under spinalanaesthesia. The patients who match our inclusion and exclusion criteria, andthose who give a valid written informed consent, shall be divided into threegroups, each receiving one of the three vasopressor agents if they develophypotension following spinal anaesthesia. We shall be observing the incidenceand magnitude of maternal hypotension following spinal anaesthesia. We shallalso be documenting the incidence of, as well as the magnitude of decrease infall in BP , the amount of drug dosages of each vasopressor agent required forthe same, neonatal APGAR scores at 1 minute and 5 minutes, and the incidence ofmaternal post-operative nausea and vomiting.