The influence of the adjunctive use of a probiotic losenge during supportive periodontal therapy
Not Applicable
Recruiting
- Conditions
- Chronic periodontitisK05.3
- Registration Number
- DRKS00015318
- Lead Sponsor
- Funktionsbereich Parodontologie der Poliklinik für Zahnerhaltung und Parodontologie am Universitätsklinikum Leipzig AöR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
after active periodontal therapy
minimum 16 natural teeth
2 – 8 sites with probing depth = 5 mm or 4 mm + BOP positive, not an adjacent teeth
Exclusion Criteria
age < 18 years
periodontitis in relation to systemic diseases
intake of immunsuppressive or immunmodulating drugs
intake of antibiotics during the last 3 months
gravidity or lactation
tumors
smoking >5 cigarettes/day
special nutrition habits (e.g. vegetarian or functional food/probiotics)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Probing depth in mm and bleeding on probing in % using a periodontal probe after six months.
- Secondary Outcome Measures
Name Time Method attachment level in mm measured using a periodontal probe, after 3 and 6 months<br>IL-1beta and MMP-8 in the gingival crevicular fluid after 3 and 6 months via ELISA-technique<br>bacteria in the subgingival biofilm via PCR-technique after 3 and 6 months