Effects of Lidocaine Infusion on Quality of Recovery and Agitation After Functional Endoscopic Sinus Surgery: Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- quality of postoperative recovery
研究概览
简要总结
The essential anesthesia requirements for FESS include airway management, considerations for facilitating surgical access, provision of a clear and still surgical field for precision surgery, assuring quick and non-stimulating emergence from anesthesia, and fast-tracking patients for discharge. Postoperative agitation, although short-lived, is potentially harmful to both patients and recovery room staff, it has a potential for self-injury by removing intravenous catheters, tubing, oxygen masks and nasal packs. Furthermore, very agitated patients can pose an immediate danger to operating theatre staff.
详细描述
Lidocaine is an amino amide-type short-acting local anesthetic (LA). It has a short half-life, and a favorable safety profile, and is therefore the LA of choice for continuous IV administration, it has analgesic, and anti-inflammatory effects that are induced by reduction of cytokines production through inhibition of neutrophil activation, and the analgesia may persist even after plasma concentration reduction. It can blunt the pressor response to endotracheal intubation also systemic lidocaine was effective in producing controlled hypotension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective functional endoscopic sinus surgery;
- •ASA class I-II,
- •aged (20-60 years).
排除标准
- •Body mass index >35 kg/m2
- •History of allergic reaction to local anesthetic agents especially lignocaine.
- •History of preoperative use of opioids.
- •Patients with history of uncontrolled hypertension, A-V conduction block.
- •History of sleep apnea.
研究组 & 干预措施
Lidocaine group
patients will receive a loading dose of IV lidocaine 1.5mg/kg slowly diluted with 20 ml normal saline just before induction of anesthesia, then the lidocaine infusion started at a rate of 2mg/kg/h diluted in normal saline by rate of 2 ml/ kg/h.
干预措施: Lidocaine (Drug)
Control group
patients will receive an equal volume of normal saline (both the loading, and the infusion). The infusion in both groups will be started just after induction of anesthesia induction, and continued until the end of the operation.
干预措施: Normal saline (Drug)
结局指标
主要结局
quality of postoperative recovery
时间窗: 48hours
assessed using the Quality of Recovery-40 questionnaire.8, which assesses five dimensions of recovery
Emergence agitation
时间窗: 30 minutes postoperative
using the Richmond agitation-sedation scale
次要结局
未报告次要终点
研究者
rehab zayed
Assisstant Professor of Anesthesia
Alexandria University