A Multi-Center, Double Blind, Randomized, Placebo-Controlled, Parallel Group, Flexible Dose Titration, Add-On Study of Mecamylamine 5.0 to 10 mg, in the Treatment of Major Depressive Disorder With Subjects Who Are Partial or Non- Responders to Citalopram Therapy.
Overview
- Phase
- Phase 2
- Intervention
- Mecamylamine
- Conditions
- Major Depressive Disorder
- Sponsor
- Targacept Inc.
- Enrollment
- 450
- Primary Endpoint
- HAMD-17 group mean change from baseline to endpoint and/or the proportion of subjects considered to be full responders or in remission with a HAMD-17 score less than or equal to 7 at the end of treatment.
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
Depressed patients will receive 6 weeks of citaloprma (20-40mg) therapy. Subjects who have an inadequate response (partial or non-responder) will be randomized to receive either mecamylamine (5-10mg) or placebo added to their citalopram for a further 8 weeks.
Detailed Description
This is a double blind, randomized, placebo controlled, parallel group, flexible dose titration, add-on study. Male or female subjects aged 18-70 years suffering from Major Depressive Disorder according to DSM-IV, with a HAMD-17 score greater than 21 and a CGI-Severity of Illness score greater or equal to 4, will be started on open labeled citalopram treatment. The dose of citalopram may be increased form 20mg to 40mg over a six week period, depending on investigator assessment of tolerability and efficacy. At the end of this treatment, subjects with a HAMD-17 score greater or equal to 14 and a CGI-Severity of Illness score greater or equal to 4 will be considered as partial or non-responders and will be entered into the double blind phase of the study. Subjects will be randomized to either mecamylamine or placebo for a further 8 weeks. Citalopram medication will remain constant while mecamylamine (or placebo) can be increased from 5.0 to 7.5 to 10.0mg based on investigator assessment of tolerability and efficacy. Plasma samples for citalopram assay will be collected at the start and end of the double blind phase to exclude any mecamylamine effect being due to a drug:drug interaction. Approximately 500 subjects will be entered into the open-label phase of the study and approximately 160 into the double blind phase. The study will be conducted in India and the USA.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(A) Open Phase
- •Male or female subjects aged 18-70 years.
- •Diagnosis of major depressive disorder (MDD) according to DSM-IV and confirmed via MINI diagnostic scale.
- •Able to give written informed consent.
- •HAMD-17 score greater than
- •CGI-Severity of Illness score greater than or equal to
- •No clinically significant abnormality on physical examination, vital signs, ECG or laboratory tests (biochemical, hematological, urinary) at screening.
- •Women of child bearing potential with a negative urine pregnancy test and willing to use acceptable methods of contraception.
- •(B)Double Blind Phase:
- •Subjects still to meet DSM-IV criteria for MDD.
Exclusion Criteria
- •Aged below 18 years and above 70 years.
- •Failure to meet DSM IV criteria for MDD.
- •HAMD-17 less than or equal to 21 (open-label phase only).
- •CGI Severity of Illness score less than
- •Clinically significant changes in physical examination, vital signs, ECG or laboratory tests at screening.
- •Any other co morbid psychiatric illness confirmed by MINI diagnostic scale, especially bi-polar disorder, schizophrenia or dementia.
- •Subjects with significant suicidal risk upon clinical assessment.
- •Subjects who have treatment resistant depression i.e. who have failed adequate course (daily dose and duration of treatment) of one or more antidepressants.
- •History of alcohol or drug abuse over the last 6 months.
- •History of seizures or seizure disorders.
Arms & Interventions
1
Placebo
Intervention: Mecamylamine
2
Intervention: Mecamylamine
Outcomes
Primary Outcomes
HAMD-17 group mean change from baseline to endpoint and/or the proportion of subjects considered to be full responders or in remission with a HAMD-17 score less than or equal to 7 at the end of treatment.
Time Frame: 8 weeks
Secondary Outcomes
- Montgomery Asbery depression rating sclae, Clinical Global Impression Scale - Severity, Clinical Global Impression Sacle - Change, Sheehan irritability scale, Sheehan disability scale(8 weeks)
- Blood biochemistry, urnie analysis, blood pressure, heart rate, ECG(8 weeks)
- Citalopram plasma bloods at week 6 and 14.(8 weeks)