Training-induced Cerebral Reorganization in Schizophrenia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 80
- Locations
- 2
- Primary Endpoint
- change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations
Study Overview
Brief Summary
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia
Detailed Description
Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Clinical diagnosis of schizophrenia and disorders with psychotic features
- •Intact auditory perception
- •Intact visual perception
Exclusion Criteria
- •Mental retardation
- •Age over 60
- •Insufficient German language knowledge
Arms & Interventions
Auditiory verbal discrimination training
Brain Fitness & Brain Training- Posit Science
Intervention: Brain Fitness & Brain Training- Posit Science (Behavioral)
Facial affect discrimination training
Behavioral: Facial Affect Training- FAT
Intervention: Facial Affect Training- FAT (Behavioral)
Outcomes
Primary Outcomes
change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations
Time Frame: baseline, post-intervention (after 4 weeks), 3-months follow-up
Secondary Outcomes
- change from baseline in global functioning (GAF score) at 4 weeks and 3 months(baseline, post-intervention, 3-months follow-up)
Investigators
Prof. Dr. Brigitte Rockstroh
Prof. Dr.
University of Konstanz