Phase 4 Study of the Renoprotective Efficacy of Aliskiren in Addition to Angiotensin II Receptor Blocker in Chronic Kidney Disease
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Rate of change in GFR
研究概览
简要总结
Study objective: To investigate the potential anti-proteinuric and renoprotective efficacy of aliskiren in addition to losartan in patients at risk of developing end-stage renal disease (ESRD)
Methods: This will be a randomized, double-blind study in which proteinuric, non-diabetic patients with chronic kidney disease (CKD) will be assigned in a 1:1 ratio to one of the following treatment groups for 3 years:
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Group A: Losartan (Control arm: conventional treatment)*
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Group B: Aliskiren plus Losartan (Intervention arm)*
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With optional addition of other anti-hypertensive agents to achieve an optimal target blood pressure of <130/80 mmHg.
详细描述
Aliskiren is a direct renin inhibitor that has been shown to reduce proteinuria and retard renal deterioration in type 2 diabetic patients with overt nephropathy. However, it is not known if these therapeutic effects can be extended to nondiabetic chronic renal disease. The current study aims to explore this research question by randomly assigning patients with various stages of chronic renal disease to receive either aliskiren on top of losartan, or continuation of losartan.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female 18 - 80 years of age
- •Presence of nondiabetic CKD stages 3 to 4 as defined by estimated glomerular filtration rate (eGFR by 4-variable MDRD equation) as follows:
- •Stage 3: Moderate decrease in GFR 30-59 mL/min/1.73 sq.m
- •Stage 4: Severe decrease in GFR 15-29 mL/min/1.73 sq.m
- •CKD is defined as either kidney damage or GFR <60 mL/min/1.73 m2 for > 3 months with variations of less than 30% in the 3 months before screening
- •Early-morning urinary protein-to-creatinine ratio of >500 mg/g or 57 mg/mmol on at least 2 occasions four weeks apart
- •Patients who are willing to give written, informed consent
排除标准
- •eGFR < 15 or > 60 ml/min/1.73m2
- •Early-morning urinary protein-to-creatinine ratio of >5000 mg/g or 570 mg/mmol, or urinary protein-to-creatinine ratio of <500 mg/g or 57 mg/mmol
- •Serum K+ > 5.2 mmol/L
- •Presence of bilateral renal artery stenosis
- •Known allergy to losartan or aliskiren
- •Patients who are receiving angiotensin II receptor blocker / angiotensin converting enzyme inhibitor combination within 12 weeks of randomization
- •Concurrent treatment with corticosteroids, nonsteroidal antiinflammatory drugs, or immunosuppressive agent
- •Patients with connective tissue disease or obstructive uropathy
- •Patients with concomitant malignancy or any such conditions that will severely limit life expectancy
- •Female who are pregnant or intending to conceive
- •Female of child-bearing age who are unwilling to practice effective contraception
- •Patients who are unable to give informed consent
- •Patients simultaneously participating in another study or who have participated in another study within the last 30 days of entry into this study
研究组 & 干预措施
Aliskiren
Aliskiren
干预措施: Aliskiren (Drug)
Losartan
ARB
干预措施: Losartan (Drug)
结局指标
主要结局
Rate of change in GFR
时间窗: 36 months
次要结局
- Change in proteinuria(36 months)