The microbiome and role of biofilms in Hidradenitis Suppurativa

Not Applicable

Completed

• Conditions: Inflammatory and Immune System - Other inflammatory or immune system disorders; Infection - Studies of infection and infectious agents; Skin - Dermatological conditions; Hidradenitis suppurativa

• Registration Number: ACTRN12619000802101
• Lead Sponsor: iverpool Hospital, Department of Dermatology

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-06-03
• Study Completion: 2020-07-21
• Last Update Posted: 1 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Inclusion criteria is the presence of hidradenitis suppurativa, diagnosed or having had the diagnosis confirmed by a dermatologist.

Exclusion Criteria

Patients will be excluded if they are less than 18 years of age.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determine if biofilms are present in HS using microscopy.<br><br>[Single skin biopsies collection];Explore the microbial diversity, community structure and function (Microbiome) of HS and the differences between disease stages. This is a composite outcome. This will be assessed through the sampling of patients with lesions with different stages of the disease - Hurley stage I (mild), Hurley stage II (moderate) and Hurley stage III (severe) disease. This will also be assessed through the use of 16s and shotgun genomics. [Single skin biopsies collection]

Secondary Outcome Measures

Name	Time	Method
Explore associations between host- microbiome genes and inflammatory markers. This is an exploratory outcome, and will be assessed by the use of 16s and shotgun genomics.[Single skin biopsies collection];Assess the microbial load (number of bacteria) of HS. This will be assessed through the use of electron scanning microscopy.[Single skin biopsies collection];Assess the histopathology of HS specimens. This will be assessed through histopathological examination of the samples by a pathologist.[Single skin biopsies collection]