Cybersickness imAgiNg Olfactory Evocation

Central Hospital, Nancy, France1 site in 1 country30 target enrollmentApril 13, 2022

ConditionsHealthy

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy
Sponsor: Central Hospital, Nancy, France
Enrollment: 30
Locations: 1
Primary Endpoint: Comparison of cerebral activations between the different supports mediating the olfactory imagination during the execution of the fMRI tasks.
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to, using fMRI, compare brain activations during olfactory imagery induced by different visual supports (words, pictures, colors and colored arrangements) in healthy subjects.

This will allow us to choose the best olfactory imagery facilitator and to assess its effect on cybersickness.

Registry

clinicaltrials.gov

Start Date

April 13, 2022

End Date

October 26, 2022

Last Updated

3 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Central Hospital, Nancy, France

Responsible Party

Principal Investigator

Cécile RUMEAU

Principal Investigator

Central Hospital, Nancy, France

Eligibility Criteria

Inclusion Criteria

•to be of French nationality who has always lived in metropolitan France;
•to be right-handed person;
•to be enrolled in a social security plan;
•to be able to understand the instructions given;
•to have underwent a pre-inclusion medical examination;
•to give a written consent;
•Person with a strong capacity for olfactory imagination: having obtained a score strictly below 2.5 on the fVOIQ olfactory imagination questionnaire.

Exclusion Criteria

•to have an inability to read French;
•to be recognized as a synesthete;
•to have a professional activity requires intense olfactory activity;
•to have a partial or total loss of smell (hyposmia, anosmia);
•to have qualitative smell disorders (carcosomia, hyperosmia, phantosmia, parosmia);
•to have smell disorders of neurological, post-traumatic or neurodegenerative origin;
•to have uncorrected or poorly corrected visual disturbances;
•to have vestibular disorder diagnosed;
•any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, ... );
•subject under a measure of legal protection.

Outcomes

Primary Outcomes

Comparison of cerebral activations between the different supports mediating the olfactory imagination during the execution of the fMRI tasks.

Time Frame: Baseline (J0)

The cerebral activations between the different supports mediating the olfactory imagination will be compared in terms of localization and intensity of the variations of the BOLD signal during the execution of the fMRI tasks.

Secondary Outcomes

Description of the evolution of the cardiac activity during olfactory imagination tasks in fMRI.(Baseline (J0))
Determination of the visual support allowing the strongest olfactory imagination during the fMRI by subjective evaluations using two 4-level Likert scales.(Baseline (J0))
Determination of the visual support allowing the strongest olfactory imagination during the fMRI test by the cerebral activations in areas recognized for their implications in the olfactory imagination.(Baseline (J0))
Description of the evolution of the respiratory activity during olfactory imagination tasks in fMRI.(Baseline (J0))
Evaluation of the state of discomfort in virtual reality by measuring the cardiac activity.(Baseline (J0) and 6 months maximum after J0 (V1))
Evaluation of the state of discomfort in virtual reality by the "Simulator Sickness Questionnaire" (SSQ) before and after immersion.(Baseline (J0) and 6 months maximum after J0 (V1))