The Berlin 'Cream&Sugar' Study: the Prognostic Impact of an Oral Triglyceride Tolerance Test in Patients After Acute Ischemic Stroke
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- First Ischemic Stroke
- Sponsor
- Charite University, Berlin, Germany
- Enrollment
- 573
- Locations
- 1
- Primary Endpoint
- Recurrent Stroke
- Last Updated
- 9 years ago
Overview
Brief Summary
Non-fasting triglyceride levels are thought to play a role in stroke. The investigators hypothesise that the results of a standardised oral triglyceride tolerance test in the subacute setting (3-7 days) after the first ischaemic stroke are associated with the risk of recurrent stroke within 12 months after the index event.
Detailed Description
Since high postprandial triglycerides levels may be a risk factor for stroke, we use a combined oral triglyceride and glucose tolerance test in patients who had a first ischemic stroke. Follow-up after one year primarily assesses wether or not a recurrent stroke has occured. The glucose tolerance test is meant to identify patients with metabolic syndrome (and diabetes), since this condition is per se associated with increased levels of triglycerides. Potentially, the post-challenge triglyceride levels only play a role in patients without diabetes or metabolic syndrome. For further details see Ebinger et al. 'The Berlin 'Cream\&Sugar' Study: the prognostic impact of an oral triglyceride tolerance test in patients after acute ischaemic stroke', IJS; 2010,5, 47-51.
Investigators
Martin Ebinger
PD Dr. med. Dr. phil.
Charite University, Berlin, Germany
Eligibility Criteria
Inclusion Criteria
- •Age over 18 years
- •First ischemic stroke
- •Incidence within less than 7 days
- •Informed consent obtained
Exclusion Criteria
- •Aphasia (if hampering informed consent)
- •Swallowing disorder
- •Pregnancy
- •Renal or hepatic failure
- •Pancreatitis
- •Cholecystolithiasis
- •Malabsorption
- •Lactose intolerance
- •Psychosis
- •Drug and/or alcohol addiction
Outcomes
Primary Outcomes
Recurrent Stroke
Time Frame: outcome measure is assessed one year after first ischemic stroke.
The primary end-point of the study is a recurrent fatal or nonfatal stroke within the first 12 months after the event.
Secondary Outcomes
- MI(one year after first ischemic stroke)
- death(one year after first ischemic stroke)
- TIA(one year after first ischemic stroke)