Measurements of major respiratory muscle by ultrasonography for separation from artificial ventilation machine in patients with hospital acquired pneumonia

Completed

• Conditions: Pneumonia, unspecified organism,

• Registration Number: CTRI/2019/09/021292
• Lead Sponsor: Dr Mohammad Hashim

Brief Summary

Nosocomial pneumonia is the second most commonhospital-acquired infection and associated with increased ICU days, Ventilatordays, morbidity and mortality in ICU patients. Mechanicalventilation is the crucial and integral element in ICU and saves many lives butdifficult and delayed weaning is associated with diaphragmatic dysfunctionbecause of contractile dysfunction and atrophy and associated with increasedmorbidity and mortality, so weaning should be considered earliest possible buton another side, premature withdrawal from mechanical ventilation is alsoassociated with increased morbidity and mortality. 

Morerecently, lung and diaphragm ultrasound methods have been introduced, assessingpulmonary airway patterns and diaphragm function. In the present study, we aim toidentify the role of diaphragmatic thickness fraction and excursion as measuredby ultrasonography in weaning from mechanical ventilation in the patients withnosocomial pneumonia.

In this study sample will be divided in to two groups on the basis of Diaphragmatic Thickness Fraction(DTF), one with DTFof >30% and other with DTF of <30% then primary and secondaryoutcomes will be prospectively followed in these groups by the researcher who will be blinded toDiaphragmatic ultrasonography findings, for at least 72 hours or till the patient will be discharged from theICU.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-28
• Study Completion: 2020-12-31
• Last Update Posted: 2021-09-06

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients aged ≥ 18 years with nosocomial pneumonia and on Mechanical Ventilation for more than 24 hours and satisfying conventional criteria for ready to wean from ventilator and undergoing for Spontaneous breathing trial.

Exclusion Criteria

• Patients aged < 18 years, ventilated for less than 24 h 2.
• Patients with pre-existing diaphragm disease or any neuromuscular disorder.
• Patients with increased intra-abdominal pressure 4.
• Patients with any breach in skin preventing DUS examinations in Sub-costal area 5.
• Phrenic nerve palsy 6.
• Pregnancy 7.
• Morbid obesity (BMI>40).
• Patients deteriorated after 30 minutes of application of SBT.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify the role of diaphragmatic ultrasound predictors: DTF for predicting the success of weaning from mechanical ventilation in icu patients with Nosocomial Pneumonia	28 days

Secondary Outcome Measures

Name	Time	Method
To identify the effect of diaphragmatic excursion (DE) and other measures (RSBI, PImax, Dynamic compliance, P 0.1) on weaning outcome in mechanically ventilated patients with nosocomial pneumonia in ICU.	28 days

Trial Locations

Locations (1)

All India Institute of Medical Sciences, Rishikesh; 🇮🇳 Dehradun, UTTARANCHAL, India

All India Institute of Medical Sciences, Rishikesh

🇮🇳Dehradun, UTTARANCHAL, India

Dr Mohammad Hashim

Principal investigator

9760171584

buxhashim@gmail.com