Molecular markers to delineate excision margins in head and neck squamous cell cancer - a bilateral prospective study in Australia and India

Not Applicable

Completed

• Conditions: Head and neck squamous cell carcinoma; Cancer - Head and neck

• Registration Number: ACTRN12616000715471
• Lead Sponsor: Rama Jayaraj

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-30
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All patients diagnosed with mucosal head and neck squamous cell carcinoma with negative surgical margins on histopathology at the Royal Darwin Hospital and Christian Medical College Vellore

Exclusion Criteria

Patients diagnosed with any other histological type of mucosal head and neck cancers, and whose primary modality of therapy was surgery.
*Patients whose surgical margins showed dysplasia, carcinoma – in – situ, tumour and was less than 5mm distant from invasive tumour on histopathological examination
*Patients with metastatic disease except a single regional lymph node with no extracapsular spread
*Patients with multiple foci of peri-neural invasion
Patients with lymphovascular invasion
*Patients with previous radiotherapy and chemotherapy
*Patients in whom the margins cannot be defined or with an unknown primary
*Patients under 18 years of age
*Patients who are pregnant

Study & Design

• Study Type: Observational
• Study Design: Not specified