Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Change in Achilles tendon cross-sectional area
研究概览
简要总结
The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double-blind, randomized controlled trial
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •No subjective symptoms during physical exertion
- •Stable weight and dietary behaviour
- •Body Mass Index (BMI) between 18.5 and 24.9
- •No extensive strength/endurance sports so far (less than 3 h/week)
- •No complaints during strenuous physical activity
排除标准
- •Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
- •Intolerance/aversion to animal protein
- •Arterial hypertension (high blood pressure) (syst > 200 mmHg and/or diast > 105 mmHg) at rest
- •Presence of insulin-dependent diabetes mellitus
- •Liver and/or kidney disease that precludes a high protein load
- •Collagen supplementation or regular intake of other dietary supplements in the last 6 months.
结局指标
主要结局
Change in Achilles tendon cross-sectional area
时间窗: Baseline and after 12 weeks
Measured by ultrasound
Change in Vastus Lateralis fibre length
时间窗: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by ultrasound
Change in collagen related blood markers
时间窗: Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
Measured by blood analysis
Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)
时间窗: Baseline and after 12 weeks
Measured by bioelectrical impedance analysis
Change in maximal voluntary contraction (MVC)
时间窗: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by isokinetic dynamometer
Change in rate of force development (RFD)
时间窗: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by isokinetic dynamometer
Change in countermovement jump height (CMJ)
时间窗: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by force plate
Change in subjective pain score
时间窗: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
Measured by visual analogue scale
Change in Achilles tendon echo intensity
时间窗: Baseline and after 12 weeks
Measured by ultrasound
Change in Vastus Lateralis echo intensity
时间窗: Baseline and after 12 weeks
Measured by ultrasound
次要结局
未报告次要终点
研究者
Daniel König
Univ.-Prof. Dr. med. Daniel König
University of Vienna