The Role of Statins in the Prevention of Contrast-induced Acute Kidney Injury in Patients With Cardiovascular Diseases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Contrast-induced acute kidney injury
研究概览
简要总结
The aim of the study is to assess the role of statins and different dosage regimens in the prevention of contrast-induced acute kidney injury in patients with cardiovascular diseases requiring intravenous contrast media administration before computer tomography
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Written informed consent
- •Indications for computer tomography with intravenous contrast media administration
- •Cardiovascular diseases (arterial hypertension, arrhythmia etc)
排除标准
- •Pregnancy
- •Statin therapy before inclusion in the study
- •Acute coronary syndromes
- •Contraindications for statins administration
- •Patients with chronic kidney disease stages 4-5
- •Contraindications for computer tomography with contrast media administration
- •Nephrotoxic drugs use (NSAIDS, vancomycin etc)
研究组 & 干预措施
Control group
No statins being used for prevention
干预措施: Atorvastatin (Drug)
Low-dose statin therapy
Atorvastatin 40 mg
干预措施: Atorvastatin (Drug)
High-dose statin therapy
Atorvastatin 80 mg
干预措施: Atorvastatin (Drug)
结局指标
主要结局
Contrast-induced acute kidney injury
时间窗: 48-72 hours after contrast media administration
Contrast induced acute kidney injury is defined as the 25% rise (or 0,5 mg/dl) of serum creatinine from baseline assessed 48 hours after administration of contrast media.
次要结局
未报告次要终点
研究者
Olga Mironova
Associate Professor
I.M. Sechenov First Moscow State Medical University