Internal Jugular Vein Distensibility and Pleth Variability Index(PVI) for Evaluating Fluid Responsiveness

Completed

• Conditions: Intravascular Volume
• Interventions: Procedure: Assessment of fluid responsiveness

• Registration Number: NCT03673475
• Lead Sponsor: Tepecik Training and Research Hospital

Brief Summary

Assessment of intravascular volume status is crucial in order to predict the efficacy of volume status in major abdominal surgery. The aim of the study is to verify the feasibility and usefulness of the internal jugular vein distensibility index as an adjunct to the pleth variebility index(PVI) to predict fluid responsiveness in major abdominal surgery.

Detailed Description

Forty patients above age 18 and ASA status I-III who are undergoing major abdominal surgery will be enrolled in the study. patients with right heart failure, arrythmia, severe valve stenosis or regurgitation will be excluded. After induction of general anesthesia, when the patients are hemodynamically stabilised, PVI and jugular vein distensibility will be calculated and recorded. after volume load with 500 ml gel infusion(in 15 min), measurements will be repeated within 10 minutes and recorded. Patients will be allocated to 2 groups according to the change in mean arterial pressure(MAP) after volume expansion: Responders will be defined as an increase in MAP by \>%10; while nonresponders will be defined as an increase in MAP \<%10 or decrease in MAP.

Study Timeline

• Study Start: 2018-02-01
• Study First Submitted: 2018-08-24
• Study First Submitted QC: 2018-09-14
• Study First Posted: 2018-09-17
• Primary Completion: 2018-09-30
• Study Completion: 2018-09-30
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-23
• Last Update Posted: 2018-11-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• American Society of Anesthesiologists(ASA) physical status I-III patients
• patients undergoing major abdominal surgery

Exclusion Criteria

• arrythmia
• severe right ventricle failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
fluid responsiveness	Assessment of fluid responsiveness	Assessment of fluid responsiveness using pleth variebility index and jugular vein distensibility in patients undergoing major abdominal surgery

Primary Outcome Measures

Name	Time	Method
number of patients with significant change in VJI distensibility and pleth variebility index	during surgery at day 0	volume responders with significant change in jugular vein distensibility and pleth variebility index

Trial Locations

Locations (1)

Tepecik Training and Research Hospital; 🇹🇷 Izmir, Turkey