Posterior Circulation Clot Burden Score (Pc-CBS) Predicts Clinical Outcome After Acute Ischemic Stroke Related to Posterior Circulation Occlusions : An Externally Validated Radiological Score

Completed

• Conditions: Acute Ischemic Stroke; Arterial Occlusion Disease; Posterior Circulation Brain Infarction

• Registration Number: NCT07122934
• Lead Sponsor: Centre Hospitalier Universitaire Vaudois

Brief Summary

Posterior circulation strokes (PCS) represent \~30% of all ischemic strokes, but existing prognostic tools are limited, especially for non-basilar artery occlusions. Accurate early outcome prediction may aid treatment decisions and clinical trial design. We developed and externally validated the Posterior Circulation Clot Burden Score (PC-CBS), a radiological tool to predict 3-month functional outcome in acute ischemic stroke due to posterior circulation occlusion.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-02-01
• Primary Completion: 2023-03-31
• Status Verified: 2025-08
• Study Completion: 2025-08-08
• Study First Submitted: 2025-08-08
• Study First Submitted QC: 2025-08-08
• Last Update Submitted: 2025-08-08
• Study First Posted: 2025-08-14
• Last Update Posted: 2025-08-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1828

Inclusion Criteria

• age >18 years old
• admitted within 24h from last known well
• symptomatic arterial occlusion. The following arterial occlusions were eligible for inclusion: the extracranial vertebral artery between the V0 and V3 segments; the intracranial portion of the vertebral artery; the basilar artery either in its proximal, mid and/or distal segment, the P1 and/or the P2 segments of the posterior cerebral artery.

Exclusion Criteria

• simultaneous clinical and/or radiological strokes in the posterior and anterior circulation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Modified rankin scale at three months	3 months