Comparing the starting time of tacrolimus administration in management of kidney transplant recipients
Phase 3
- Conditions
- Kidney transplant.Kidney transplant status
- Registration Number
- IRCT201604253043N11
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
All patients who underwent the first of Deceased donor or Living donor kidney transplantation in Imam Khomeini Hospital Complex, Tehran, Iran ; Age is = 14 y ; Patients who receive thymoglobulin induction ; Patients who receive Mycophenolate and Prednisone plus Tacrolimus as immunosuppressive regimen.
Exclusion criteria: Patients with unstable cardiac, hepatic, pulmonary functions after kidney transplantation ; Patients who have multiple organ transplantation ; Patients with known malignancy.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Recipient's serum creatinine. Timepoint: Before the transplantation, every 6 hours on the first day of transplant, then daily during hospitalization, then weekly until the end of the first month after transplant, then monthly until the end of the third month after transplat. Method of measurement: Blood samples in laboratories in milligrams / deciliter.;Recipient's urine output. Timepoint: Before transplantation and daily during hospitalization. Method of measurement: Graduated container in ml/day.;Incidence of DGF. Timepoint: During first week after transplantation. Method of measurement: Need for dialysis.
- Secondary Outcome Measures
Name Time Method Graft survival. Timepoint: First three months after transplantation. Method of measurement: Number of functioning kidney.;The incidence of acute rejection. Timepoint: During the first three months after transplantation. Method of measurement: Based on function of transplanted kidney.