A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 811
- 试验地点
- 183
- 主要终点
- Banking of tumor cells and germline DNA
研究概览
简要总结
This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.
详细描述
OBJECTIVES:
I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.
II. Make these specimens available to qualified researchers to study the biology of ALL.
OUTLINE: This is a multicenter study.
Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma
- •In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or peripheral blood
- •Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis of relapse
- •No concurrent systemic antileukemic treatment administered for current relapse
- •Intrathecal chemotherapy allowed
- •On-therapy relapse allowed
排除标准
- 未提供
结局指标
主要结局
Banking of tumor cells and germline DNA
时间窗: Not Provided
次要结局
未报告次要终点