A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 2,545
- 试验地点
- 192
- 主要终点
- Repository of malignant, borderline malignant neoplasms, and related biological specimens
研究概览
简要总结
This study is collecting and storing malignant, borderline malignant neoplasms, and related biological samples from young patients with cancer. Collecting and storing samples of tumor tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help the study of cancer in the future.
详细描述
OBJECTIVES:
I. Collect malignant, borderline malignant neoplasms, and related biological specimens from Children's Oncology Group institutions for cases in which there is no disease-specific biologic protocol.
II. Provide a repository for long-term storage of malignant, borderline malignant neoplasms, and related biological specimens from these patients.
III. Make specimens available to qualified researchers to understand the biology of cancer in these patients.
OUTLINE:
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- — 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meets any of the following criteria:
- •Diagnosed with primary neoplasm
- •Developed a second malignant neoplasm
- •Any diagnoses having an ICD-O Morphology Code ending in 1, 2, or 3 as listed in the International Classification of Disease for Oncology, Third Edition
- •Must have biological specimens including solid tumors and leukemias available
- •Solid tumors meeting the following criteria:
- •Snap frozen primary tumor OR OCT embedded primary tumor OR formalin fixed (block or tissue in formalin) primary tumor AND at least 10 unstained paraffin slides for NIH Mandated QC (tumors that have undergone central pathology review are allowed)
- •Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
- •Pleural fluid or cytologic specimens meeting the following criteria:
- •At least 1 mL of fluid and at least 2 unstained cytospin slides (or 2 unstained smears)
- •Slides for pathology review (instead of slides for QC) are required for patients with rare tumors
- •3-6 mL of bone marrow aspirate and 10 mL of whole blood
- •Not eligible for disease-specific biology or banking protocol
排除标准
- 未提供
结局指标
主要结局
Repository of malignant, borderline malignant neoplasms, and related biological specimens
时间窗: Baseline
次要结局
未报告次要终点