Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

Completed

• Conditions: Childhood Cerebral Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Grade I Meningioma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Medulloblastoma; Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Supratentorial Ependymoma; Ependymoma; Newly Diagnosed Childhood Ependymoma; Childhood Craniopharyngioma

• Registration Number: NCT00919750
• Lead Sponsor: Children's Oncology Group

Brief Summary

The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory. Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

Detailed Description

OBJECTIVES:

I. Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions.

II. Provide a repository for long-term storage of specimens from these patients.

III. Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study.

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

Study Timeline

• Study Start: 2004-02-16
• Study First Submitted: 2009-06-11
• Study First Submitted QC: 2009-06-11
• Study First Posted: 2009-06-12
• Primary Completion: 2018-06-30
• Study Completion: 2018-06-30
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-12
• Last Update Posted: 2018-07-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1258

Inclusion Criteria

• Diagnosis of brain tumor

• Previously treated at a Children?s Oncology Group (COG) institution

  • Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm

• Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children?s Oncology Group institutions	Up to 16 years
Creation of a repository for long-term storage of these specimens	Up to 16 years
Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors	Up to 16 years

Trial Locations

Locations (187)

Children's Hospital of Alabama; 🇺🇸 Birmingham, Alabama, United States

University of Alabama at Birmingham Cancer Center; 🇺🇸 Birmingham, Alabama, United States

Phoenix Childrens Hospital; 🇺🇸 Phoenix, Arizona, United States

Arkansas Children's Hospital; 🇺🇸 Little Rock, Arkansas, United States

University of Arkansas for Medical Sciences; 🇺🇸 Little Rock, Arkansas, United States

Kaiser Permanente Downey Medical Center; 🇺🇸 Downey, California, United States

City of Hope Comprehensive Cancer Center; 🇺🇸 Duarte, California, United States

Loma Linda University Medical Center; 🇺🇸 Loma Linda, California, United States

Miller Children's and Women's Hospital Long Beach; 🇺🇸 Long Beach, California, United States

Children's Hospital Los Angeles; 🇺🇸 Los Angeles, California, United States

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