Comparison of the Haemodynamic effects of nasal intermittent positive pressure ventilation and nasal continuous positive pressure ventilation in preterm neonates with respiratory distress syndrome - a randomised controlled trial
Phase 4
- Conditions
- Health Condition 1: P220- Respiratory distress syndrome of newborn
- Registration Number
- CTRI/2024/04/065278
- Lead Sponsor
- Bharati vidyapeeth deemed university Pune Maharashtra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Preterm neonates admitted to NICU during the study period of
gestational age 26 to 36+6/7 weeks, who have received invasive mechanical ventilation, surfactant atherapy and then extubated to non-invasive respiratory support (NIPPV or NCPAP).
Exclusion Criteria
1)major congenital malformation
2)extubation failure within 24hrs requiring reintubation
3)neonatal sepsis
4)inotropic support in last 24 hrs
5)moderate to severe HIE
6)haemodynamically significant PDA
7)moderate to severe pulmonary hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the right ventricular systolic and diastolic functions in preterm infants on NIPPV versus NCPAP, 4-6 hours and 18-24 hours after extubation using Fn ECHO. <br/ ><br>To compare the left ventricular systolic and diastolic functions in preterm infants on NIPPV versus NCPAP, 4-6 hours and 18-24 hours after extubation using Fn ECHO. <br/ ><br>Timepoint: 4-6 hours and 18-24 hours
- Secondary Outcome Measures
Name Time Method ILTimepoint: NI