Assessment of Different Disinfection Protocols on Regenerative Potential of Mature Teeth

Not Applicable

Completed

• Conditions: Apical Periodontitis
• Interventions: Other: Method

• Registration Number: NCT05557994
• Lead Sponsor: Minia University

Brief Summary

Regenerative endodontic procedures have been used to successfully treat human mature permanent teeth with necrotic pulps and apical periodontitis. Many researchers have begun to apply regenerative endodontic procedures to mature teeth in adult patients. Several clinical case reports have shown complete resolution of signs and symptoms of pulp necrosis in mature teeth, even those with large periapical lesions, as well as signs of pulp canal obliteration. The aim of this study is to assess the regenerative potential of mature permanent teethwith necrotic pulps after disinfecting the root canal using diode laser andcompare it with dynamic agitation of xp-endo finisher and conventionaltriple antibiotic paste

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-15
• Primary Completion: 2022-06-15
• Study Completion: 2022-07-20
• Status Verified: 2022-09
• Study First Submitted: 2022-09-24
• Study First Submitted QC: 2022-09-24
• Last Update Submitted: 2022-09-24
• Study First Posted: 2022-09-28
• Last Update Posted: 2022-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

Patients with mature teeth. Patients with periapical periodontitis. Maxillary anterior teeth only will be involved. Patients should be free from any systemic disease that may affect normal healing and predictable outcome.

Patients who will agree to the consent and will commit to follow up period.

Exclusion Criteria

• Patients with immature roots. - Immuno-compromised patients, including patients who self-reportedto be a carrier of HIV, hepatitis, undergoing steroid therapy, thosewho self-reported with genetic or systemic diseases that could resultin a reduced immune response.- All patients who respond positive to allergic patch test [tripleantibiotic paste] and drugs.- Pregnant and lactating women.- Patients who could/would not participate in a 1-year follow-up.- Teeth with previous endodontic therapy performed. - Teeth with periodontal involvement. - Teeth with calcified canals.- Presence of external or internal root resorption.- Teeth with root fractures (checked with pre-operative radiographsusing horizontal and vertical angulations)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Blood clotting	Method	Blood clotting protocol for pulp regeneration of mature teeth
Disinfection technique	Method	Compare different disinfection technique

Primary Outcome Measures

Name	Time	Method
Clinical success	9 months	pulp vitality testing using electric pulp tester which detect response of pulp to electric current

Secondary Outcome Measures

Name	Time	Method
Radiographic success	9 months	healing of apical periodontitis by detecting change in apical radiolucency and absences of apical bone resorption

Trial Locations

Locations (1)

Abanoub Raouf; 🇪🇬 Banī Suwayf, Bani Suwayf, Egypt