Improved Erectile Function After Bariatric Surgery: Role of Testosterone and Other Factors
- Conditions
- Bariatric SurgeryErectile Dysfunction
- Interventions
- Procedure: Sleeve gastrectomy
- Registration Number
- NCT06527170
- Lead Sponsor
- Jagiellonian University
- Brief Summary
The prevalence of obesity has risen dramatically worldwide. Beyond its metabolic implications, obesity profoundly impacts sexual health, particularly in males, with erectile dysfunction emerging as a prevalent and distressing comorbidity. Studies show that bariatric surgery alleviates erectile dysfunction. Patients suffering from obesity have lower testosterone levels, which increase after weight-loss surgery. This study aims to investigate the relationship between erectile dysfunction improvement, weight loss and hormonal changes after surgery.
- Detailed Description
In recent decades, the prevalence of obesity has risen dramatically worldwide, presenting significant public health concerns. Beyond its metabolic implications, obesity profoundly impacts sexual health, particularly in males, with erectile dysfunction (ED) emerging as a prevalent and distressing comorbidity. Obesity exacerbates the risk of ED through complex interplays of physiological and psychological mechanisms. Physiologically, excess adiposity leads to chronic inflammation, endothelial dysfunction, and hormonal imbalances, all of which contribute to impaired vascular health and reduced testosterone levels, key factors in erectile function. Psychologically, body image dissatisfaction and decreased self-esteem associated with obesity can exacerbate sexual performance anxiety and further contribute to ED. Bariatric surgery is an established treatment method for long-term weight loss which also alleviates symptoms of diabetes, hypertension, and other weight-related comorbidities.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 135
- patients undergoing laparoscopic sleeve gastrectomy who were qualified according to Guidelines of the International Federation for the Surgery of Obesity and Metabolic Disorders
- lack of data during follow-up visit (at 1-year).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Male patients Sleeve gastrectomy Male patients undergoing bariatric surgery
- Primary Outcome Measures
Name Time Method The International Index of Erectile Function score immediately before surgery and one year after 6 questions from IIEF official questionnare. Each question is score 1-5.
Erectile dysfunction (ED) assessed using a validated tool Patient who scored \<25 points were considered for further analysis. Each patient was categorized into severity: 25-30 no ED, 19-24 mild ED, 13-18 mild to moderate ED, 7-12 moderate ED, 0-6 severe ED.
After follow-up, patients with prior ED (\<25 IIEF) were assigned to three groups: 1 - no improvement, 2 - symptom alleviation (change in severity category), 3 - ED remission
- Secondary Outcome Measures
Name Time Method percentage of total weight loss (%TWL) one year after surgery Weight loss results
Sex hormone binding (nmol/l) immediately before surgery and one year after Laboratory test using blood samples
percentage of excess weight loss (%EWL) one year after surgery Weight loss results
luteinizing hormone (mIU/ml) immediately before surgery and one year after Laboratory test using blood samples
Testoreone (nmol/l) immediately before surgery and one year after Laboratory test using blood samples
Estradiol (pmol/l) immediately before surgery and one year after Laboratory test using blood samples
Weight loss results one year after surgery weight loss (WL) in kg
Trial Locations
- Locations (1)
2nd Department of General Surgery, Jagiellonian University Medical College
🇵🇱Kraków, Małopolska, Poland