Graded Exercise Hypoxia Testing

Recruiting

• Conditions: Hypoxia

• Registration Number: NCT06901284
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to develop a single, standardized test to determine how individuals tolerate acute hypoxia in a stepwise fashion. We aim to evaluate the association between multiple factors, such as ventilatory compensation, heart rate response, acid-base changes, sex, pulmonary function, etc, which may explain why some individuals tolerate exercise in hypoxia better than others. Identifying these factors of association will inform future pharmacological and non-pharmacological attempts to combat acute hypoxic exercise.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-03-24
• Study First Submitted QC: 2025-03-24
• Study First Posted: 2025-03-28
• Status Verified: 2025-04
• Study Start: 2025-04-15
• Last Update Submitted: 2025-04-16
• Last Update Posted: 2025-04-20
• Primary Completion: 2027-04-24
• Study Completion: 2028-04-24

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Physically active (≥150 minutes of moderate physical activity per week)

Exclusion Criteria

• Contraindications to exercise testing
• Currently pregnant
• Musculoskeletal or metabolic disease
• Allergies to lidocaine
• Body-mass index ≤18 or ≥35 kg·m-2
• Pacemaker
• No confounding cardiorespiratory disease
• Persistent tobacco use (>15 pack years)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
PaO₂/FiO₂ Ratio	30 minutes	The PaO₂/FiO₂ ratio is a widely used measure of oxygenation efficiency in the lungs. It compares the arterial oxygen partial pressure (PaO₂, measured in mmHg) to the fraction of inspired oxygen (FiO₂, expressed as a decimal). The ratio provides insight into the ability of the lungs to transfer oxygen into the bloodstream. A PaO₂/FiO₂ ratio of 300-400 is considered to be mild hypoxemia. Participants are considered as poorly tolerating hypoxia if their ratio is \<400 and good at tolerating hypoxia if their ratio is \>400.

Trial Locations

Locations (2)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States

St. Mary's Hospital; 🇺🇸 Rochester, Minnesota, United States