Preoperative ultrasonographic inferior vena cava collapsibility index and caval aorta index in predicting hypotension after subarachnoid block in patients undergoing caesarean section: a prospective observational analytical study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- AUROC value of IVCCI and CAI in predicting hypotension after subarachnoid block in patients
研究概览
简要总结
METHODOLOGY
After a detailed pre anaesthetic checkup and a written informed consent, 235 patients undergoing
caesarean section under subarachnoid block will be studied for preoperative ultrasound imaging of the
inferior vena cava collapsibility index and caval aorta index. In the operating room, subarachnoid block
will be administered and when T6 level of sensory block is achieved, surgery shall be initiated. NIBP,
PR, SpO2 measured every min for 5 mins and then every 5 mins throughout the surgery. Episodes of
hypotension shall be noted. Hypotension will be treated with bolus of 5 mg injection ephedrine
(incremental dosing) and bolus of 250 mL of Ringer’s Lactate solution over 10 minutes. Number of
boluses of injection ephedrine and fluid shall be recorded.
WHY IS THIS RESEARCH WORK NECESSARY
Subarachnoid block is preferred over general anaesthesia in caesarean sections due to its relatively safe
maternal and neonatal risk profile. However, in pregnant patients, the incidence of hypotension after
subarachnoid block is more due to various anatomical and physiological changes which can lead to
reduced preload resulting in hypotension. Due to hypotension, there can be many severe adverse
maternal and foetal adverse effects. Therefore, it is essential to assess preoperative intravascular volume
in pregnant patients so that risk of hypotension and its side effects can be avoided.
Preoperative ultrasound guided measurement of IVCCI and CAI can be helpful in assessing
preoperative intravascular volume status accurately and thus may predict hypotension. So, with our
study we aim to assess the efficacy of ultrasound assessment of IVCCI and CAI in predicting
hypotension and also find out the better predictor of post subarachnoid block hypotension.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- Female
入选标准
- •Singleton pregnancy at greater than 36 weeks.
排除标准
- •Emergency LSCS (category 1).
- •Patients in whom massive intraoperative loss is expected (placenta accreta or placenta praevia).
- •Patients who have received pre-loading of intravenous fluids.
- •Contraindications to subarachnoid block (e.g., coagulopathy, local infection).
- •Patients with known allergy to local anaesthetics.
结局指标
主要结局
AUROC value of IVCCI and CAI in predicting hypotension after subarachnoid block in patients
时间窗: At baseline in preoperative area
undergoing caesarean section
时间窗: At baseline in preoperative area
次要结局
- Positive & negative predictive values, sensitivity, & specificity of IVCCI & CAI in predicting(hypotension after subarachnoid block in patients undergoing caesarean section)
- Cut off values & AUROC of IVCCI & CAI in predicting hypotension after subarachnoid block in(patients undergoing caesarean section)
研究者
Anusha Malhotra
Lady Hardinge Medical College and SSKH
