Safety and Efficacy of Maximally Tolerated RAAS Blockade and Spironolactone Therapy on Urinary Proteinuria and Progression of Type II Diabetic Nephropathy in African Americans and Other Patient Cohorts.
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- Combination Therapy - RAAS inhibition and Spironolactone to lower UP/Cr
研究概览
简要总结
NephroNet proposes to examine whether combining Spironolactone with maximal RAAS blockade will further reduce urinary protein at one year and whether prolonged therapy (24 months) is able to slow the decline in GFR. Because of combination MRA and RAAS therapy significantly increases the risk for clinically significant hyperkalemia, we also plan to determine whether the addition of Patiromer to these patients facilitates the use of combination therapy and allows a larger proportion of diabetic patients the potential benefit of combination therapy on renal function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 75 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 18
- •Male or Female
- •Patients with Type II diabetes mellitus must be receiving oral agents or insulin injections at the time of randomization
- •All eligible patients will be on a stable, maximum to dose of an ACE or ARB for 2 weeks prior to randomization.
- •Note: The determination of m tolerated ACE-ARB therapy will be left to the discretion of the site princ
- •All eligible patientswill have hypertension targetblood pressur of < 140/90mm Hg.
- •Antihypertensiv therapy may be adjusted to achieve the target blood pressure prior to the time of randomization.
- •ACE or ARB therapy will be the primary antihypertensive therapy used for blood pressure control and will be titrthe highest tolerated dose to achieve a target blood pressure of <Patients requiring additional medications to achieve the target blood pressure will use antihypertensive agents that have neutral effects on urinary proteinuria (e.g. Hydralazine or lo Dihydropyridine calcium channel blockers etc.). CcThe final choice of additional medications will be left to the discretion of the site principal investigator (PI)
- •Patients with anurine protein to creatinine (UP/Cr) ratio that is mg/gm from the average of two historical value within one year prior to randomization will be considered eligible for study entry.
- •Patients with a baseline K+ of >
- •X5 meq/l on maximum tolerated ACE-ARB therapy during the screening period can be treated with 8.4 grams of Patiromer for 7 days. If at the end of 7days the serum K+ is < 5.0 meq/liter the patient will be considered eligible to participate in the study. If at the end of 7 days the serum K+ >5.0 meq/l the dose of Patiromer can be increased to 16.8 grams. If at the end of 7 days the serum K+ is < 5.0 meq/L, the patient will be considered eligible for study entry. If after 7 days at the higher dose of Patiromer the serum K+ >5.0, the patient will be ineligible for study participation.
- •Patients with an estimated GFR by CK-Epi .73 m2
- •Female patients will be required to undergo routine birth control measures
- •Exclusion criteria:
- •Estimated GFR by MDRD20 mls/min/1.73 M2 using the CKD-Epi equation
- •Patients with serum K+ > 5.00 while taking 16.8/day of Patiromer
- •Patients with history of Type mellitus
- •Patients with HgbA
- •Pregnant or breast-feeding female patients
- •Female patients unwilling to receive estrogen or progesterone based birth control or are unwilling or unable to usconventional barrier birth control methods.
- •Patients with known allergy or intolerance tor Spironolactone therapy
- •Patients taking oral or IV digoxin
- •Patients receiving chronic steroids > 1oral Prednisone
- •Patient that do nohave minimum o eGFR determinations within 2 years prior to study randomization
- •Concurrent use of Amiloride, , Aliskerin, or other Aldosterone antagonists Patien receiving any of the above medications will be considered eligible for study participation after a wash-out
排除标准
- 未提供
研究组 & 干预措施
RAAS alone
RAAS (Lisinopril, Enalapril, Perindopril, Losartan, and Valsartan taken each day at maximum tolerated dose that will different for each subject)
干预措施: Renin-Angiotensin (RAAS) alone (Drug)
RAAS in Combination with Spironolactone
RAAS (Lisinopril, Enalapril, Perindopril, Losartan, and Valsartan taken each day at maximum tolerated dose that will different for each subject); Spironolactone taken each day at 25mg
干预措施: Renin-Angiotensin (RAAS) blockers in combination with Spironolactone (Drug)
结局指标
主要结局
Combination Therapy - RAAS inhibition and Spironolactone to lower UP/Cr
时间窗: 24 months
To determine whether combination therapy with maximall RAAS inhibition and Spironolactone is superior to RAAS inhibition alone in lowering the UP/Cr ratio at 12 months
次要结局
- Combination Therapy - RAAS inhibition and Spironolactone(24 months)
- Combination Therapy - RAAS inhibition and Spironolactone that develop hyperkalemia(12 months, 24 months)
研究者
James A. Tumlin, MD
Sponsor-Investigator
NephroNet, Inc.