Assessment of the use of spironolactone on the endothelial glycocalyx in patients with kidney transplants

Phase 2

• Conditions: Kidney transplant; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12616000966493
• Lead Sponsor: Department of Renal Medicine, Box Hill Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Kidney transplant >1 year ago

Exclusion Criteria

Malignancy, pregnancy, inability to consent, known haematological disorders, serum potassium > 5.0 mmol/

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in glycocalyx parameters by:<br>1. Glycocheck value (sublingual camera measurement of the glycocalyx)<br>2. ELISA of syndecan-1 on serum samples<br>3. ELISA of hyaluronan on serum samples[5 months post initial randomisation of study arm]

Secondary Outcome Measures

Name	Time	Method
Change in markers of endothelial dysfunction by:<br>1. ELISA of von Willebrand Factor on serum samples<br>2. ELISA of vascular cell adhesion molecule-1 (VCAM-1) on serum samples<br>3. Urinary microalbuminuria[5 months post initial randomisation of study arm]