Pterygopalatine Fossa Block in Aneurysmal Subarachnoid Hemorrhage
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Opioid consumption
研究概览
简要总结
Aneurysmal subarachnoid hemorrhage (aSAH) can cause a severe headache (HA) that is famously treatment-resistant. Current pain regimens are too reliant on opioids, which results in long-term opioid dependence and can obfuscate the neurological examination, which is critical to detect vasospasm and delayed cerebral ischemia. This study will gather the initial evidence of whether the pterygopalatine fossa (PPF) regional anesthesia nerve block can treat aSAH-related HA and reduce opioid consumption in patients with aSAH.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aneurysmal subarachnoid hemorrhage with secured aneurysm
- •Age greater than or equal to 18 years
- •Able to communicate pain level
排除标准
- •Documented allergy to local anesthetics (e.g. bupivicaine)
- •Patients with unsecured aneurysms
- •Patients who are unable to communicate pain level (e.g. sedation/mechanical ventilation/delirium, etc)
- •Medical treatment for vasospasm including blood pressure/inotropic augmentation
- •Angiographic treatment for vasospasm within 48 hours
研究组 & 干预措施
Treatment arm
干预措施: Bupivacaine 0.25% Injectable Solution (Drug)
Treatment arm
干预措施: Ptergyopalatine Fossa Block (Procedure)
结局指标
主要结局
Opioid consumption
时间窗: 3 days
Pain Rating Scale
时间窗: 3 days
Scale of 1-10, 1 being lowest possible pain, 10 being highest possible pain
次要结局
未报告次要终点
研究者
Noah Jouett
Fellow Physician
University of Texas Southwestern Medical Center