To evaluate the relationship of mechanical power on the trend of cerebral oxygenation in critically ill patients on mechanical ventilation. A prospective observational study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- To evaluate the relationship of mechanical power on the trend of cerebral oxygenation in critically ill patients on mechanical ventilation.
研究概览
简要总结
Critically ill patients admitted for cardiorespiratory disorders require higher PEEP and PIP for adequate ventilation. Increased PEEP and PIP have been associated with reduced cerebral oxygenation. Both the PEEP and PIP are important components of Mechanical Power, and higher PEEP and PIP are associated with higher MP. Increased MP has shown deleterious effects on systemic oxygenation and cerebral perfusion in animal studies. There are no studies comparing the relationship of mechanical power on cerebral oxygenation in humans to our knowledge. Therefore, we plan to conduct a prospective observation study on the relationship of mechanical power on the trend of cerebral oxygenation in critically ill patients on mechanical ventilation.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients above 18 years admitted to ICU requiring mechanical ventilation for more than 24 hours.
排除标准
- •Pregancy Less than 18 years Head injury patients Patients with raised ICP features Patients with expected mechanical ventilation requirement of less than 24 hours.
结局指标
主要结局
To evaluate the relationship of mechanical power on the trend of cerebral oxygenation in critically ill patients on mechanical ventilation.
时间窗: Initial 24 hours of mechanical ventilation in ICU.
次要结局
- To evaluate the relation of Partial pressure of arterial oxygen (PaO2) with the mechanical power.
- To evaluate the relation of Partial pressure of arterial carbon dioxide (PaCO2) with the mechanical power.