Use of 'Mechanical Power' as a Predictor of Increased Serum and Pulmonary Proinflammatory Cytokine Concentrations in Patients With Acute Hypoxemic Respiratory Failure: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Patients who exceed 17 J/min of MP
研究概览
简要总结
The aim of this study is to report the proportion of patients with acute hypoxemic respiratory failyre (AHRF) undergoing mechanical ventilation who exceed 17 J/min of mechanical power (MP) and the difference in terms of proinflammatory cytokine concentration in blood samples and bronchoalveolar lavage.
The main questions it aims to answer are:
- Which is the proportion of patients who exceed 17 J/min of mechanical power (MP) during the first 72 hours of mechanical ventilation?
- Is there a difference in terms of cytokine concentration in patients undergoing mechanical power >17 J/min compared to <17 J/min?
Patients will be divided into two groups based on respiratory mechanics measurements: low MP group (average MP <17 J/min) and high MP group (average MP ≥17 J/min). The researchers will collect blood and BAL samples and perform cytokine assays.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with AHRF (P/F <300 mmHg) undergoing invasive mechanical ventilation within 7 days from the onset of symptoms
- •Invasive mechanical ventilation for less than 6 hours
- •Evidence of newly developed lung consolidation on chest imaging (X-ray, CT)
- •Age ≥18 years
排除标准
- •Prior invasive mechanical ventilation during the same hospitalization
- •Tracheostomy
- •Severe anemia (Hb<7g/dL)
- •Severe neutropenia
- •Renal insufficiency or RRT (Renal Replacement Therapy)
- •Noradrenaline >0.5 mcg/kg/min
- •Pregnancy
- •Extracorporeal circulation (ECCO2R, ECMO)
- •Life expectancy <24 hours as clinically judged
- •Lack of consent
结局指标
主要结局
Patients who exceed 17 J/min of MP
时间窗: 4 years
Proportion of patients with AHRF undergoing mechanical ventilation who exceed 17 J/min of MP
次要结局
- Inflammatory cytokines(4 years)
研究者
Francesco Alessandri
Prof
University of Roma La Sapienza