Interleukin 33 in Juvenile Idiopathic Arthritis Patients :Relation to Disease State and Muscloskeletal Ultrasound Findings

disease activity for systemic arthritis with active systemic features (and without active arthritis)

时间窗: through study completion, an average of 4 months

DISEASE ACTIVITY LEVELS (2 levels) Active fever AND physician global assessment of overall disease activity 7 of 10 Active fever AND systemic features of high disease activity (e.g., significant serositis) that result in physician global assessment of overall disease activity 7 of 10

physician's global assessment of disease activity scale

时间窗: through study completion, an average of 4 months.

physician's global assessment of disease activity on a 0- 10 cm visual analogue scale (VAS). Higher value indicates worse outcome

The 27-joint Juvenile Arthritis Disease Activity Score (JADAS-27)

时间窗: through study completion, an average of 4 months

The JADAS-27 (range 0-57) was computed by summing the scores of four core-set criteria \[3\]: physician's global assessment of disease activity (PGA) on a 10 cm visual analogue scale (VAS); parent/patient global assessment of well-being on a 10 cm VAS \[7\]; active arthritis, defined as joint swelling or limitation of movement accompanied by pain and tenderness, assessed in 27 joints; and ESR (mm/h) normalized to a 0-10 scale, using the formula ESR - 20/10, whereby, before the calculation, ESR values \<20 mm/h were converted to 0 and ESR values \>120 mm/h were converted to 120. A higher JADAS-27 indicates higher disease activity and a lower JADAS-27 indicates lower disease activity

grey scale 10 joint score

时间窗: through study completion, an average of 4 months

grey scale musculoskeletal ultrasound including 10-joints (bilateral knee, ankle, wrist, elbow and the 2nd metacarpophalangeal (MCP) joints)

parent/patient global assessment of well-being scale

时间窗: through study completion, an average of 4 months.isit to measure IL33

parent/patient global assessment of well-being on a 0-10 cm visual analogue scale .Higher value indicates worse outcome

C reactive protein (CRP)

时间窗: through study completion, an average of 4 months

CRP measured in mg/L using nephlometry

Serum ferritin level

时间窗: through study completion, an average of 4 months

Serum ferritin level measured in ng/mL using elisa

Erythrocyte sedimentation rate (ESR)

时间窗: through study completion, an average of 4 months

ESR measured in mm/1st hour by westergren method

rheumatoid factor

时间窗: through study completion, an average of 4 months

rheumatoid factor measured in U/ml using latex agglutination test

disease activity for systemic arthritis with active arthritis (and without active systemic features)

时间窗: through study completion, an average of 4 months

Low disease activity (must satisfy all) 4 or fewer active joints, ESR or CRP level normal PGA of disease activity less than4 of, 10 PAGA of well-being 2 of 10 Moderate disease activity (does not satisfy criteria for low or high disease activity) High disease activity (must satisfy at least 3) 8 or more active joints,ESR or CRP level greater than twice upper limit of normal, PGA of disease activity 7 of 10, PAGA of well-being 5 of 10

27 active joints count

时间窗: through study completion, an average of 4 months

active arthritis, defined as joint swelling or limitation of movement accompanied by pain and tenderness, assessed in 27 joints

power Doppler 10 joint score

时间窗: through study completion, an average of 4 months

power Doppler musculoskeletal ultrasound including 10-joints (bilateral knee, ankle, wrist, elbow and the 2nd metacarpophalangeal (MCP) joints)

The Juvenile Arthritis Multidimensional Assessment Report

时间窗: through study completion, an average of 4 months

The JAMAR is a questionnaire includes the following 15 sections: Assessment of physical function (PF) using 15-items with score 0-45. Higher scores indicating higher degree of disability 2. 21-numbered circle Visual Analogue Scale (VAS) for pain 3. Assessment of the presence of joint pain or swelling.4.Assessment of morning stiffness 5. extra-articular symptoms (fever and rash) 6.disease activity on a 21-circle VAS. 7.disease status. 8. course. 9.medications . 10. side effects. 11.difficulties with medication 12. school/university/work problems. 13. HRQoL 14.patient's overall well-being on a 21-numbered circle VAS. 15. satisfaction with outcome.