The Metabolic Effects of a High Fructose Versus a High Glucose Diet in Overweight Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 2
- 主要终点
- Liver triglyceride content
研究概览
简要总结
Dietary consumption of fructose has increased by nearly 50% since 1960.
A high fructose diet (HFrD) results in greater visceral adiposity and systemic insulin resistance than a high glucose diet. The effects of fructose on liver fatty acid and ATP stores, systemic oxidative stress and cardiovascular status are not fully known.
详细描述
The protocol will assess the following outcomes:
- The ultimate fate of this increased hepatic fatty acid production following a high fructose vs. glucose diet
- The effect of a high fructose vs. glucose diet on liver ATP stores
- The effect of a high fructose vs. glucose diet on markers of oxidative stress
- The effect of a high fructose vs. glucose diet on cardiovascular status
Factors critical to carbohydrate metabolism such as systemic insulin resistance, body composition, energy expenditure, physical activity will also be assessed.
32 centrally overweight healthy males with a low baseline fructose intake will be recruited. They will be randomised double blindly to receive 25% of their dietary energy requirements from either fructose or glucose for 14 days.
The sugars will first be taken in an energy balanced and then an overfeeding setting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Body mass index 25-32
- •Waist > hip circumference
- •Age 18-50 years
排除标准
- •Reported weight change > 3 kg in prior 3/12
- •Active health problems
- •Contraindications to MRI scanning
- •Symptoms of functional bloating or irritable bowel syndrome
- •Abnormal liver or renal function tests
- •Random glucose greater than 11.0 mmol/L
- •Evidence of metabolic or viral liver disease as screened for by hepatitis B and C serology, and ferritin.
- •Alcohol intake > 21 units per week
- •Vegetarianism
- •Normal daily fructose intake from drinks greater than that in 500ml of coca cola
- •Abnormal carbohydrate energy contribution to baseline diet - defined as greater than 2 standard deviations from the mean of the National Diet and Nutrition Survey 2002 data
结局指标
主要结局
Liver triglyceride content
时间窗: 2 weeks
次要结局
- Liver ATP, PME concentration and pH (31P MRS)(2 weeks)
- Hepatic and systemic insulin resistance(2 weeks)
- Cardiovascular measures using finometry(2 weeks)
- Muscle triglyceride content(2 weeks)
- Total abdominal visceral fat content (MRI)(2 weeks)
- Liver de novo lipogenesis(2 weeks)
- Resting energy expenditure, lipid and carbohydrate oxidation rates(2 weeks)
- Systemic oxidative stress and inflammatory cytokine profile(2 weeks)