Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 2
- 主要终点
- Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion.
研究概览
简要总结
In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity.
The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged from 18 to 40 years
- •Body Mass Index of 18.5 to 25 kg/m²
- •Sex male of female
排除标准
- •Fructose intolerance
- •Antidiabetic and hypolipemic drugs
- •Alcohol consumption >10g/day
- •Severe eating disorders
- •Severe psychological problems
- •Vegetarian diet or other specific diet
- •Consumption of illicit substances
- •Pregnancy
- •Weight gain or weight loss > 3 kg in the last 3 months
研究组 & 干预措施
Test meal
The subjects will receive a liquid test meal containing glucose and fructose with 13C fructose.
干预措施: Test meal (Other)
结局指标
主要结局
Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion.
时间窗: The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min.
Calculation with 13C fructose enrichment in blood samples at T0; 30; 60; 90; 120; 150; 180; 210 and 240 min.
次要结局
未报告次要终点
研究者
Luc Tappy, MD
MD, Professor
University of Lausanne