Autoimmune Diabetes: Disease Markers and Treatment of Latent Autoimmune Diabetes in Adults (LADA)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- T-reg
研究概览
简要总结
Autoimmunity is the main cause of diabetes type 1 and an important factor as cause of Latent Autoimmune Diabetes in Adults (LADA). Recently, research has found that being deficient of T-reg cells is an important cause of autoimmunity. The study hypothesis are:
- Patients with newly found diabetes type 1 have less T-reg than healthy.
- Patients with newly found diabetes type 1 have less T-reg than patients with long duration of the illness.
- The number of T-reg is negative associated with HLA-risk-haplotype.
- The number of T-reg is negative associated with LADA.
- Differences relating to inflammatory cytokines will be seen among patients with newly found diabetes type 1, but not among others.
详细描述
Research has worked out that b-cells are being destroyed by cytokines released from inflammatory cells. One hypothesis in that T-reg is a cause of autoimmunity, and that T-reg concentrations are low in patients with newly diagnosed diabetes type 1.
Blood samples will be taken from 10 patients with newly diagnosed type 1 diabetes, Latent Autoimmune Diabetes in Adults (LADA) and type 1 diabetes older than 10 years and the same amount of samples from healthy, age- and sex-matched blood donors. Markers of autoimmune diabetes will be analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •newly diagnosed diabetes type 1
- •diabetes type 1 older than 10 years
排除标准
- 未提供
结局指标
主要结局
T-reg
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次要结局
- HLA, anti-GAD, anti-IA2, white blood count, CRP, fasting C-peptide, HbA1c