Identification of Genetic changes and other factors in hereditary breast and ovarian cancer
- Conditions
- Health Condition 1: C50- Malignant neoplasm of breastHealth Condition 2: C569- Malignant neoplasm of unspecifiedovary
- Registration Number
- CTRI/2020/02/023574
- Lead Sponsor
- Dr T M A Pai Fellowship
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Known mutation in cancer susceptibility gene within the family
Any patient with male breast cancer
Personal history of breast cancer with one or more of following
Early age of onset
If diagnosed at <60 years of age with TNBC
Diagnosed at any age with:
One or more close blood relative with breast cancer diagnosed at <50 years
Two or more close blood relative with breast cancer at any age
One or more close blood relative with invasive ovarian cancer
Close male blood relative breast cancer.
Cancer individual without a family history
Early death due to cancer or non-cancerous conditions
Any psychological or genetic disorder with mental retardation
Adoption and limited family size
Patient not willing for genetic testing genetic counseling
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ï??To identify the frequency types and genetic variants of germline mutations among the patient presenting with high risk of hereditary cancer by NGS Cancer risk assessment based on the genetic and non-genetic factors in patient and at-risk family memberTimepoint: 3years
- Secondary Outcome Measures
Name Time Method Presence of other non-genetic confounding factors and comparison between incidence of nongenetic factor among the patient with average and high risk and To develop a genetic variation database for public health purposeTimepoint: 3years